Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Bayesian semiparametric mixed effects models for meta-analysis of the literature data : An application to cadmium toxicity studies

Authors
Jo, SeongilPark, BeomjoChung, YeonseungKim, JeongseonLee, EunjiLee, JangwonChoi, Taeryon
Issue Date
7월-2021
Publisher
WILEY
Keywords
cadmium toxicity; dose& #8208; response relationship; literature data; measurement error; shape restriction
Citation
STATISTICS IN MEDICINE, v.40, no.16, pp.3762 - 3778
Indexed
SCIE
SCOPUS
Journal Title
STATISTICS IN MEDICINE
Volume
40
Number
16
Start Page
3762
End Page
3778
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137569
DOI
10.1002/sim.8996
ISSN
0277-6715
Abstract
We propose Bayesian semiparametric mixed effects models with measurement error to analyze the literature data collected from multiple studies in a meta-analytic framework. We explore this methodology for risk assessment in cadmium toxicity studies, where the primary objective is to investigate dose-response relationships between urinary cadmium concentrations and beta 2-microglobulin. In the proposed model, a nonlinear association between exposure and response is described by a Gaussian process with shape restrictions, and study-specific random effects are modeled to have either normal or unknown distributions with Dirichlet process mixture priors. In addition, nonparametric Bayesian measurement error models are incorporated to flexibly account for the uncertainty resulting from the usage of a surrogate measurement of a true exposure. We apply the proposed model to analyze cadmium toxicity data imposing shape constraints along with measurement errors and study-specific random effects across varying characteristics, such as population gender, age, or ethnicity.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Political Science & Economics > Department of Statistics > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Tae ryon photo

Choi, Tae ryon
정경대학 (통계학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE