Open reading frame 5 protein of porcine circovirus type 2 induces RNF128 (GRAIL) which inhibits mRNA transcription of interferon-beta in porcine epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Kang, Seok-Jin | - |
dc.contributor.author | Park, In-Byung | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.accessioned | 2022-03-03T17:41:34Z | - |
dc.date.available | 2022-03-03T17:41:34Z | - |
dc.date.created | 2022-03-02 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0034-5288 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137649 | - |
dc.description.abstract | A previous study has indicated that mRNA transcript of Rnf128 (Grail) is significantly increased in porcine epithelial cells expressing porcine circovirus type 2 (PCV2) open reading frame 5 (ORF5). RNF128 is an E3 ubiquitin ligase that can modulate the activity of target protein via ubiquitination of specific lysine residues. However, the function of RNF128 in PCV2-infected epithelial cells has not been well studied yet. Thus, the objective of the present study was to examine the functional role of RNF128 in porcine epithelial cells (PK15 cells) after PCV2 infection. Results clearly indicated that PCV2 ORF5 increased the expression of RNF128 which inhibited type I IFN production and enhanced viral replication of PCV2 in PK15 cells. Therefore, up-regulating RNF128 by PCV2 ORF5 can help PCV2 circumvent initial immune surveillance of porcine epithelial cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | E3 UBIQUITIN LIGASE | - |
dc.subject | VIRAL REPLICATION | - |
dc.subject | ORF3 PROTEIN | - |
dc.subject | EXPRESSION | - |
dc.subject | VIRUS | - |
dc.subject | INFECTION | - |
dc.subject | DISEASE | - |
dc.subject | PIGS | - |
dc.title | Open reading frame 5 protein of porcine circovirus type 2 induces RNF128 (GRAIL) which inhibits mRNA transcription of interferon-beta in porcine epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Taehoon | - |
dc.identifier.doi | 10.1016/j.rvsc.2021.08.002 | - |
dc.identifier.scopusid | 2-s2.0-85112548023 | - |
dc.identifier.wosid | 000703894700010 | - |
dc.identifier.bibliographicCitation | RESEARCH IN VETERINARY SCIENCE, v.140, pp.79 - 82 | - |
dc.relation.isPartOf | RESEARCH IN VETERINARY SCIENCE | - |
dc.citation.title | RESEARCH IN VETERINARY SCIENCE | - |
dc.citation.volume | 140 | - |
dc.citation.startPage | 79 | - |
dc.citation.endPage | 82 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | E3 UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ORF3 PROTEIN | - |
dc.subject.keywordPlus | PIGS | - |
dc.subject.keywordPlus | VIRAL REPLICATION | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordAuthor | ORF5 | - |
dc.subject.keywordAuthor | PCV2 | - |
dc.subject.keywordAuthor | Porcine epithelial cell | - |
dc.subject.keywordAuthor | RNF128 | - |
dc.subject.keywordAuthor | Type I IFN | - |
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