Targeted therapy response in early versus late recurrence of renal cell carcinoma after surgical treatment: A propensity score-matched study using the Korean Renal Cancer Study Group database
DC Field | Value | Language |
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dc.contributor.author | Lee, Chan Ho | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Jeong, Chang Wook | - |
dc.contributor.author | Seo, Seong Il | - |
dc.contributor.author | Kang, Minyong | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Song, Cheryn | - |
dc.contributor.author | Park, Jae Young | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Lee, Hakmin | - |
dc.contributor.author | Ku, Ja Yoon | - |
dc.contributor.author | Seo, Won Ik | - |
dc.contributor.author | Choi, Seock Hwan | - |
dc.contributor.author | Ha, Hong Koo | - |
dc.date.accessioned | 2022-03-03T22:40:34Z | - |
dc.date.available | 2022-03-03T22:40:34Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 0919-8172 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137671 | - |
dc.description.abstract | Objectives: To investigate the clinicopathological features and outcomes of targeted therapy in patients with recurrence of renal cell carcinoma in < 5 years or >= 5 years after the surgical treatment for renal cell carcinoma. Methods: Patients with metastatic renal cell carcinoma treated with targeted therapy in a multicenter database were retrospectively characterized according to time from surgery to recurrence. Early recurrence was defined as recurrence within 5 years after surgery, and late recurrence was defined as occurring >= 5 years after surgery. The propensity scores for recurrence status were calculated, and patients with late recurrence were matched to patients with early recurrence at a 1:3 ratio. The oncological outcomes of targeted therapy in both groups were compared. Results: Among 716 patients, 512 (71.5%) experienced early recurrence and 204 (28.5%) experienced late recurrence. The patients with late recurrence presented with younger age at surgery, lower tumor stages and Fuhrman grade, and fewer sarcomatoid features and lymphovascular invasion (all P < 0.005). All differences in clinicopathological characteristics before targeted therapy disappeared after matching. Patients with late recurrence had significantly longer median overall survival (56 months vs 36 months; P < 0.0001) and median first-line progression-free survival (12 months vs 8 months; P = 0.031). The early recurrence status was a significantly worse predictor for overall survival and first-line progression-free survival (hazard ratio 1.30, P = 0.007; and hazard ratio 1.76, P < 0.001, respectively). Conclusions: Late recurrence might have prognostic value in terms of oncological outcomes in metastatic renal cell carcinoma treated with targeted therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Targeted therapy response in early versus late recurrence of renal cell carcinoma after surgical treatment: A propensity score-matched study using the Korean Renal Cancer Study Group database | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jae Young | - |
dc.identifier.doi | 10.1111/iju.14485 | - |
dc.identifier.scopusid | 2-s2.0-85100101251 | - |
dc.identifier.wosid | 000613528400001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF UROLOGY, v.28, no.4, pp.417 - 423 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF UROLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF UROLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 423 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordAuthor | late recurrence | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | renal cell carcinoma | - |
dc.subject.keywordAuthor | targeted therapy | - |
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