Kinetics of Serological Response in Patients with Severe Fever with Thrombocytopenia Syndrome
DC Field | Value | Language |
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dc.contributor.author | Ra, Sang Hyun | - |
dc.contributor.author | Kim, Min Jae | - |
dc.contributor.author | Kim, Min-Chul | - |
dc.contributor.author | Park, Se Yoon | - |
dc.contributor.author | Park, Seong Yeon | - |
dc.contributor.author | Chong, Yong Pil | - |
dc.contributor.author | Lee, Sang-Oh | - |
dc.contributor.author | Choi, Sang-Ho | - |
dc.contributor.author | Kim, Yang Soo | - |
dc.contributor.author | Lee, Keun Hwa | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.contributor.author | Kee, Sun-Ho | - |
dc.date.accessioned | 2022-03-05T04:40:21Z | - |
dc.date.available | 2022-03-05T04:40:21Z | - |
dc.date.created | 2022-03-02 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137819 | - |
dc.description.abstract | Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). We investigated the detailed kinetics of serologic response in patients with SFTS. Twenty-eight patients aged >= 18 years were enrolled between July 2015 and October 2018. SFTS was confirmed by detecting SFTSV RNA in their plasma using reverse transcription polymerase chain reaction. SFTSV-specific IgG and IgM were measured using immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA). We found that SFTSV-specific IgG was detected at days 5-9 after symptom onset, and its titer was rising during the course of disease. SFTSV-specific IgM titer peaked at around week 2-3 from symptom onset. The SFTSV-specific seropositive rates for days 5-9, 10-14, 15-19, and 20-24 from symptom onset using IFA and ELISA were 63%, 76%, 90%, and 100%, and 58%, 86%, 100%, and 100%, respectively, for IgG, whereas they were 32%, 62%, 80%, and 100%, and 53%, 62%, 70%, and 100%, respectively, for IgM. The delayed IgM response could be attributed to the low sensitivity of SFTSV-specific IgM IFA or ELISA and/or impaired immune responses. The IgM test using IFA or ELISA that we used in this study is, therefore, insufficient for the early diagnosis of SFTS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Kinetics of Serological Response in Patients with Severe Fever with Thrombocytopenia Syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kee, Sun-Ho | - |
dc.identifier.doi | 10.3390/v13010006 | - |
dc.identifier.scopusid | 2-s2.0-85099115884 | - |
dc.identifier.wosid | 000610815400001 | - |
dc.identifier.bibliographicCitation | VIRUSES-BASEL, v.13, no.1 | - |
dc.relation.isPartOf | VIRUSES-BASEL | - |
dc.citation.title | VIRUSES-BASEL | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordAuthor | enzyme-linked immunosorbent assay (ELISA) | - |
dc.subject.keywordAuthor | immunofluorescence assay (IFA) | - |
dc.subject.keywordAuthor | immunoglobulin G (IgG) | - |
dc.subject.keywordAuthor | immunoglobulin M (IgM) | - |
dc.subject.keywordAuthor | severe fever with thrombocytopenia syndrome (SFTS) | - |
dc.subject.keywordAuthor | viral load | - |
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