FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish
DC Field | Value | Language |
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dc.contributor.author | Jeong, Inyoung | - |
dc.contributor.author | Yun, Seongsik | - |
dc.contributor.author | Shahapal, Anu | - |
dc.contributor.author | Cho, Eun Bee | - |
dc.contributor.author | Hwang, Sun Wook | - |
dc.contributor.author | Seong, Jae Young | - |
dc.contributor.author | Park, Hae-Chul | - |
dc.date.accessioned | 2022-03-06T04:40:50Z | - |
dc.date.available | 2022-03-06T04:40:50Z | - |
dc.date.created | 2022-02-11 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137944 | - |
dc.description.abstract | Family with sequence similarity 19 (chemokine (C-C motif)-like) member A5 (FAM19A5) is a chemokine-like secretory protein recently identified as involved in the regulation of osteoclast formation, post-injury neointima formation, and depression. Although roles for FAM19A5 have been described in nervous system development and psychiatric disorders, its role in the nervous system remains poorly understood. Here, we analyzed the evolutionary history of FAM19A genes in vertebrates and identified FAM19A5l, a paralogous zebrafish gene originating from a common ancestral FAM19A5 gene. Further, zebrafish FAM19A5l is expressed in trigeminal and dorsal root ganglion neurons as well as distinct neuronal subsets of the central nervous system. Interestingly, FAM19A5l(+) trigeminal neurons are nociceptive neurons that localized with TRPA1b and TRPV1 and respond to mustard oil treatment. Behavioral analysis further revealed that the nociceptive response to mustard oil decreases in FAM19A5l-knockout zebrafish larvae. In addition, TRPA1b and NGFa mRNA levels are down- and upregulated in FAM19A5l-knockout and -overexpressing transgenic zebrafish, respectively. Together, our data suggest that FAM19A5l plays a role in nociceptive responses to mustard oil by regulating TRPA1b and NGFa expression in zebrafish. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | BRAIN-SPECIFIC CHEMOKINE | - |
dc.subject | TRPA1 CHANNELS | - |
dc.subject | NEURAL-CREST | - |
dc.subject | ION CHANNELS | - |
dc.subject | PROTEIN | - |
dc.subject | NEURONS | - |
dc.subject | GENE | - |
dc.subject | THERMOSENSATION | - |
dc.subject | EXPRESSION | - |
dc.subject | SPECIFICATION | - |
dc.title | FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hae-Chul | - |
dc.identifier.doi | 10.1007/s12035-021-02449-z | - |
dc.identifier.scopusid | 2-s2.0-85108860710 | - |
dc.identifier.wosid | 000666835400001 | - |
dc.identifier.bibliographicCitation | MOLECULAR NEUROBIOLOGY, v.58, no.9, pp.4770 - 4785 | - |
dc.relation.isPartOf | MOLECULAR NEUROBIOLOGY | - |
dc.citation.title | MOLECULAR NEUROBIOLOGY | - |
dc.citation.volume | 58 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 4770 | - |
dc.citation.endPage | 4785 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | BRAIN-SPECIFIC CHEMOKINE | - |
dc.subject.keywordPlus | TRPA1 CHANNELS | - |
dc.subject.keywordPlus | NEURAL-CREST | - |
dc.subject.keywordPlus | ION CHANNELS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | THERMOSENSATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SPECIFICATION | - |
dc.subject.keywordAuthor | Nociception | - |
dc.subject.keywordAuthor | Mustard oil | - |
dc.subject.keywordAuthor | TRPA1b | - |
dc.subject.keywordAuthor | NGFa | - |
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