체외수정시술을 받는 여성에서 평균 신체활동량과 6개월 내 임신 성공 여부: 전향적 난임부부 코호트 연구

Abstract

Purpose: This study aimed to assess the association between physical activity and pregnancy in 6 months among infertile women who underwent in vitro fertilization (IVF). Methods: The participants included in this study were infertile women who underwent IVF at Cha Fertility Center in Seoul Station from October 2019 to February 2020. Of 132 women who agreed to participate in the study, one was eliminated for omitting the exercise questionnaire. A survey assessing the level of physical activity of infertile women was conducted using the Korean version of the International Physical Activity Questionnaires. We calculated metabolic equivalent tas k-minutes (MET-min) scores and obtained their IVF results after 6 months of the survey. Participants with less than 3,000 MET-min were classified into the minimally active group, and those with ≥3,000 MET-min were classified as the healthenhancing group. The 2 groups were compared based on age, anti-Müllerian hormone levels, body mass index, infertility duration, nulliparity, harmful alcohol drinking, history of smoking, obesity, male factors, and pregnancy rates. Adjusted relative risk for pregnancy was calculated using log-binomial regression analysis. Results: There was no significant difference in basal characteristics between the less active and healthenhancing groups. When controlling for all covariates, the relative risk for pregnancy was close to null with health-enhancing activity. The adjusted pregnancy rate decreased with increasing MET-min in the generalized additive model. Conclusion: We observed no positive association between physical activity and pregnancy rate among interfile women undergoing IVF. To confirm our findings, subsequent interventional studies would be needed.