Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, S.-Y. | - |
dc.contributor.author | Lee, S.I. | - |
dc.contributor.author | Min, B.-W. | - |
dc.contributor.author | Oh, S.C. | - |
dc.date.accessioned | 2022-03-09T20:42:52Z | - |
dc.date.available | 2022-03-09T20:42:52Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/138389 | - |
dc.description.abstract | Purpose: The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients. Methods: A total of 965 patients with resectable CRC were divided into young (≤ 50 years, n = 101) and old groups (>51 years, n = 864). Neutrophil-to-lymphocyte ratio (NLR) > 5, derived NLR (dNLR) > 3, lymphocyte-to-monocyte ratio (LMR) < 2, platelet-to-lymphocyte ratio (PLR) > 150, and prognostic nutritional index (PNI) < 45 were analyzed for prognosis. Overall survival (OS) and progression-free survival (PFS) were compared using the log-rank test. A multivariate analysis was performed using a Cox proportional hazards regression model. Results: In the young group, NLR > 5, LMR < 2, and PNI < 45 were significantly associated with OS with univariate analyses. dNLR > 3 and those markers showed significance for PFS. LMR < 2 was a significant marker for poor PFS (hazard ratio [HR], 5.81; P = 0.020) in the multivariate analysis. In the old group, all inflammatory markers were significantly associated with OS and PFS with univariate analyses. LMR < 2 (HR, 2.66; P = 0.016) and PNI < 45 (HR, 2.14; P = 0.016) were independently associated with OS in multivariate analyses. PLR > 150 (HR, 1.45; P = 0.036) and PNI < 45 (HR, 1.73; P = 0.002) were significant markers for PFS. Conclusion: Systemic inflammation might be on e of biologic factors that influence on prognosis of young CRC. Copyright © 2021, the Korean Surgical Society. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Surgical Society | - |
dc.title | Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, B.-W. | - |
dc.contributor.affiliatedAuthor | Oh, S.C. | - |
dc.identifier.doi | 10.4174/ASTR.2021.100.1.25 | - |
dc.identifier.scopusid | 2-s2.0-85100048836 | - |
dc.identifier.wosid | 000651120600004 | - |
dc.identifier.bibliographicCitation | Annals of Surgical Treatment and Research, v.100, no.1, pp.25 - 32 | - |
dc.relation.isPartOf | Annals of Surgical Treatment and Research | - |
dc.citation.title | Annals of Surgical Treatment and Research | - |
dc.citation.volume | 100 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 25 | - |
dc.citation.endPage | 32 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002664176 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | LYMPHOCYTE RATIO | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | EARLY-ONSET | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | NEUTROPHIL | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Systemic inflammatory markers | - |
dc.subject.keywordAuthor | Young patients | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.