The Usefulness of FEF25-75 in Predicting Airway Hyperresponsiveness to Mannitol
DC Field | Value | Language |
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dc.contributor.author | Kim, Youlim | - |
dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Chung, Sung Jun | - |
dc.contributor.author | Yeo, Yoomi | - |
dc.contributor.author | Park, Tai Sun | - |
dc.contributor.author | Park, Dong Won | - |
dc.contributor.author | Min, Kyung Hoon | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Moon, Ji-Yong | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.date.accessioned | 2022-03-12T01:40:19Z | - |
dc.date.available | 2022-03-12T01:40:19Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1178-6965 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/138662 | - |
dc.description.abstract | Background and Objective: Despite the usefulness of airway hyperresponsiveness (AHR) testing in diagnosing and monitoring asthma, it is challenging to perform in a real-world setting. Forced expiratory flow between 25% and 75% of vital capacity (FEF25-75), a pulmonary measurement that can be obtained easily during routine spirometry, represents the status of medium-sized and small airways. However, the performance of FEF25-75 in predicting AHR has not been well elucidated. Therefore, we investigated whether FEF25-75 can predict AHR to mannitol. Methods: We performed a retrospective cohort study of 428 patients who visited a single clinic due to cough, wheezing, or dyspnea. All patients underwent spirometry with a mannitol provocation test. We compared the area under the curve (AUC) of the percentage of the predicted values of FEF25-75 (FEF25-75 %pred) with that of forced expiratory volume in 1 second (FEV1% pred), FEV1 forced vital capacity (FVC), and FEF25-75/ FVC for predicting AHR. Results: The rate of AHR to mannitol was 20.3%. In the overall study population, the AUC of FEF25-75 %pred for predicting AHR (0.772; 95% confidence interval [CI], 0.729-0.811) was significantly higher than that of FEV1%pred (0.666; 95% CI, 0.619-0.710; p < 0.001), FEV1/FVC (0.741; 95% CI, 0.697-0.782; p = 0.047), and FEF25-75/FVC (0.741, 95% CI = 0.696-0.782, p = 0.046). The sensitivity, specificity, positive predictive value, and negative predictive value of FEF25-75 %pred <81% for predicting AHR in the overall study population were 77.0% (95% CI = 66.8-85.4%), 63.9% (95% CI = 58.6-69.0), 35.3%, and 91.6%, respectively. When we restricted the study group to subjects with normal lung function, the results were similar. Conclusion: Our results indicate that FEF25-75%pred can be used as a surrogate for predicting AHR in patients with respiratory symptoms. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.subject | FORCED EXPIRATORY FLOW | - |
dc.subject | BRONCHIAL HYPERRESPONSIVENESS | - |
dc.subject | CHALLENGE TESTS | - |
dc.subject | VITAL CAPACITY | - |
dc.subject | ASTHMA | - |
dc.subject | IMPAIRMENT | - |
dc.subject | METHACHOLINE | - |
dc.subject | MANAGEMENT | - |
dc.subject | 75-PERCENT | - |
dc.subject | 25-PERCENT | - |
dc.title | The Usefulness of FEF25-75 in Predicting Airway Hyperresponsiveness to Mannitol | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyung Hoon | - |
dc.identifier.doi | 10.2147/JAA.S318502 | - |
dc.identifier.scopusid | 2-s2.0-85118276873 | - |
dc.identifier.wosid | 000712865100001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ASTHMA AND ALLERGY, v.14, pp.1267 - 1275 | - |
dc.relation.isPartOf | JOURNAL OF ASTHMA AND ALLERGY | - |
dc.citation.title | JOURNAL OF ASTHMA AND ALLERGY | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1267 | - |
dc.citation.endPage | 1275 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | FORCED EXPIRATORY FLOW | - |
dc.subject.keywordPlus | BRONCHIAL HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | CHALLENGE TESTS | - |
dc.subject.keywordPlus | VITAL CAPACITY | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | METHACHOLINE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | 75-PERCENT | - |
dc.subject.keywordPlus | 25-PERCENT | - |
dc.subject.keywordAuthor | forced expiratory flow between 25% and 75% of vital capacity | - |
dc.subject.keywordAuthor | mannitol | - |
dc.subject.keywordAuthor | bronchial hyperresponsiveness | - |
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