Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
DC Field | Value | Language |
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dc.contributor.author | Kim, Sunwon | - |
dc.contributor.author | Lee, Jong-Seok | - |
dc.contributor.author | Kim, Yong-Hyun | - |
dc.contributor.author | Kim, Jin-Seok | - |
dc.contributor.author | Lim, Sang-Yup | - |
dc.contributor.author | Kim, Seong Hwan | - |
dc.contributor.author | Kim, Minjung | - |
dc.contributor.author | Ahn, Jeong-Cheon | - |
dc.contributor.author | Song, Woo-Hyuk | - |
dc.date.accessioned | 2022-03-14T12:42:16Z | - |
dc.date.available | 2022-03-14T12:42:16Z | - |
dc.date.created | 2022-03-14 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/138949 | - |
dc.description.abstract | Balloon-injured coronary segments are known to harbor abnormal vasomotion. We evaluated whether de novo coronary lesions treated using drug-coated balloon (DCB) are prone to vasospasm and how they respond to ergonovine and nitrate. Among 132 DCB angioplasty recipients followed, 89 patients underwent ergonovine provocation test at 6-9 months follow-up. Within-subject ergonovine- and nitrate-induced diameter changes were compared among three different sites: DCB-treated vs. angiographically normal vs. segment showing prominent vasoreactivity (spastic). No patient experienced clinically refractory vasospastic angina or symptom-driven revascularization during follow-up. Ergonovine induced vasospasm in seven patients; all were multifocal spasm either involving (n = 2) or rather sparing DCB-treated segments (n = 5). None showed focal spasm that exclusively involved DCB-treated lesions. Among 27 patients with vasospastic features, DCB-treated segments showed less vasoconstriction than spastic counterparts (p < 0.001). A total of 110 DCB-treated lesions were analyzed to assess vasomotor function. Vasomotor function, defined as a combined constrictor and dilator response, was comparable between DCB-treated and angiographically normal segments (p = 0.173), while significant differences were observed against spastic counterparts (p < 0.001). In our study, DCB-treated lesions were not particularly vulnerable to vasospasm and were found to have vasomotor function similar to angiographically normal segments, supporting safety of DCB-only strategy in treating de novo native coronary lesions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ADIPOSE-TISSUE INFLAMMATION | - |
dc.subject | TERM-FOLLOW-UP | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | ENDOTHELIUM | - |
dc.subject | VASOCONSTRICTION | - |
dc.subject | ERGONOVINE | - |
dc.subject | DISEASE | - |
dc.subject | INJURY | - |
dc.subject | SEROTONIN | - |
dc.subject | SPASM | - |
dc.title | Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sunwon | - |
dc.identifier.doi | 10.3390/jcm11020299 | - |
dc.identifier.scopusid | 2-s2.0-85122311866 | - |
dc.identifier.wosid | 000757071000001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.11, no.2 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE INFLAMMATION | - |
dc.subject.keywordPlus | TERM-FOLLOW-UP | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ENDOTHELIUM | - |
dc.subject.keywordPlus | VASOCONSTRICTION | - |
dc.subject.keywordPlus | ERGONOVINE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | SPASM | - |
dc.subject.keywordAuthor | drug-coated balloon | - |
dc.subject.keywordAuthor | de novo lesion | - |
dc.subject.keywordAuthor | vasospasm | - |
dc.subject.keywordAuthor | coronary vasomotor function | - |
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