MST1 mediates the N-methyl-d-aspartate-induced excitotoxicity in mouse cortical neurons
DC Field | Value | Language |
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dc.contributor.author | Lim, Jane Melissa | - |
dc.contributor.author | Lee, Rumi | - |
dc.contributor.author | Kim, Yeonsil | - |
dc.contributor.author | Lee, In Young | - |
dc.contributor.author | Kim, Eunju | - |
dc.contributor.author | Choi, Eui-Ju | - |
dc.date.accessioned | 2022-03-14T13:42:28Z | - |
dc.date.available | 2022-03-14T13:42:28Z | - |
dc.date.created | 2022-03-14 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/138953 | - |
dc.description.abstract | Excessive activation of the ionotropic N-methyl-d-aspartate (NMDA) receptor has been shown to cause abnormally high levels of Ca2+ influx, thereby leading to excitotoxic neuronal death. In this study, exposure of mouse primary cortical neurons to NMDA resulted in the cleavage and activation of mammalian sterile 20-like kinase-1 (MST1), both of which were mediated by calpain 1. In vitro cleavage assay data indicated that calpain 1 cleaves out the autoinhibitory domain of MST1 to generate an active form of the kinase. Furthermore, calpain 1 mediated the cleavage and activation of wild-type MST1, but not of MST1 (G339A). Intriguingly, NMDA/calpain-induced MST1 activation promoted the nuclear translocation of the kinase and the phosphorylation of histone H2B in mouse cortical neurons, leading to excitotoxicity. Thus, we propose a previously unrecognized mechanism of MST1 activation associated with NMDA-induced excitotoxic neuronal death. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | STE20-LIKE PROTEIN-KINASE | - |
dc.subject | HISTONE H2B | - |
dc.subject | CALPAIN | - |
dc.subject | GLUTAMATE | - |
dc.subject | DEATH | - |
dc.subject | ACTIVATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | CLEAVAGE | - |
dc.subject | PATHWAY | - |
dc.subject | GENERATION | - |
dc.title | MST1 mediates the N-methyl-d-aspartate-induced excitotoxicity in mouse cortical neurons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Eui-Ju | - |
dc.identifier.doi | 10.1007/s00018-021-04103-2 | - |
dc.identifier.scopusid | 2-s2.0-85122088186 | - |
dc.identifier.wosid | 000736480700001 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR LIFE SCIENCES, v.79, no.1 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.title | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.volume | 79 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | STE20-LIKE PROTEIN-KINASE | - |
dc.subject.keywordPlus | HISTONE H2B | - |
dc.subject.keywordPlus | CALPAIN | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordAuthor | Calcium-dependent cleavage | - |
dc.subject.keywordAuthor | Glutamate receptor | - |
dc.subject.keywordAuthor | Histone H2B | - |
dc.subject.keywordAuthor | Neurotoxicity | - |
dc.subject.keywordAuthor | Protein kinase | - |
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