Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Clinical implications of thoracic duct dilatation in patients with chronic liver disease

Authors
Park, Seung WoonKim, Tae HyungHam, Soo-YounUm, Soon HoGoh, Hyun GilLee, SunHyeLee, Han AhYim, Sun YoungSeo, Yeon SeokYim, Hyung JoonAn, HyungginOh, Yu-Whan
Issue Date
29-5월-2020
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
ascites; esophageal and gastric varices; liver cirrhosis; thoracic duct
Citation
MEDICINE, v.99, no.22
Indexed
SCIE
SCOPUS
Journal Title
MEDICINE
Volume
99
Number
22
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/139072
DOI
10.1097/MD.0000000000019889
ISSN
0025-7974
Abstract
This study aimed to investigate the association between the degree of thoracic duct dilatation and the progression of chronic liver disease. In this cross-sectional and retrospective study, 179 patients (mean age, 60.9 years; 114 men) with chronic liver disease who underwent chest CT were enrolled. Dilatation of the left distal thoracic ducts (DTD) was measured and divided into the following 3 grades according to the maximum transverse diameter: grade 0, invisible thoracic duct; grade 1, visible duct with <5-mm diameter; grade 2, diameter of >= 5 mm. Statistical analyses were conducted using the binary logistic regression model. The proportion of grade 2 DTD was notably higher as the chronic liver disease progressed to cirrhosis. Visible DTD on chest CT was significantly related to the presence of cirrhosis (odds ratio [OR], 3.809;P = .027) and significant varix (OR, 3.211;P = .025). Grade 2 DTD was observed more frequently in patients with ascites (OR, 2.788;P = .039). However, 40% of patients with cirrhosis and ascites still exhibited no visible DTD while demonstrating significant amount of ascites, and their ascites were more predominant of recent onset and transient than that observed in other patients (85.7% vs 48.4%,P = .010 and 66.7% vs 29.0%,P = .009, respectively). The degree of thoracic duct dilatation is significantly associated with progression to cirrhosis and advancement of portal hypertension. Further, insufficient lymph drainage to DTD might contribute to the development of ascites.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yim, Hyung Joon photo

Yim, Hyung Joon
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE