Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Jin Gu | - |
dc.contributor.author | Yoon, Jung | - |
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Yoon, Soo-Young | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.contributor.author | Seong, Hye | - |
dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Cheong, Hee Jin | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.date.accessioned | 2022-03-15T13:42:33Z | - |
dc.date.available | 2022-03-15T13:42:33Z | - |
dc.date.created | 2021-12-24 | - |
dc.date.issued | 2020-05-25 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139073 | - |
dc.description.abstract | Background: Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period. Methods: We evaluated the viral dynamics in various body fluid specimens, such as nasopharyngeal swab, oropharyngeal swab, saliva, sputum, and urine specimens, of two patients with COVID-19 from hospital day 1 to 9. Additional samples of the saliva were taken at 1 hour, 2 hours, and 4 hours after using a chlorhexidine mouthwash. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load was determined by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Results: SARS-CoV-2 was detected from all the five specimens of both patients by rRT-PCR. The viral load was the highest in the nasopharynx (patient 1= 8.41log(10) copies/mL; patient 2 = 7.49 log(10) copies/mL), but it was also remarkably high in the saliva (patient 1= 6.63 log in copies/mL; patient 2 = 7.10 log in copies/mL). SARS-CoV-2 was detected up to hospital day 6 (illness day 9 for patient 2) from the saliva of both patients. The viral load in the saliva decreased transiently for 2 hours after using the chlorhexidine mouthwash. Conclusion: SARS-CoV-2 viral load was consistently high in the saliva; it was relatively higher than that in the oropharynx during the early stage of COVID-19. Chlorhexidine mouthwash was effective in reducing the SARS-CoV-2 viral load in the saliva for a short-term period. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Jung | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.contributor.affiliatedAuthor | Yoon, Soo-Young | - |
dc.contributor.affiliatedAuthor | Lim, Chae Seung | - |
dc.contributor.affiliatedAuthor | Noh, Ji Yun | - |
dc.contributor.affiliatedAuthor | Cheong, Hee Jin | - |
dc.contributor.affiliatedAuthor | Kim, Woo Joo | - |
dc.identifier.doi | 10.3346/jkms.2020.35.e195 | - |
dc.identifier.scopusid | 2-s2.0-85085360180 | - |
dc.identifier.wosid | 000536143700010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.35, no.20 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 35 | - |
dc.citation.number | 20 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002587883 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | Chlorhexidine | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | Saliva | - |
dc.subject.keywordAuthor | Viral Load | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.