Association of the IL16 Asn1147Lys polymorphism with intravenous immunoglobulin resistance in Kawasaki disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Hea-Ji | - |
dc.contributor.author | Kim, Jae-Jung | - |
dc.contributor.author | Yun, Sin Weon | - |
dc.contributor.author | Yu, Jeong Jin | - |
dc.contributor.author | Yoon, Kyung Lim | - |
dc.contributor.author | Lee, Kyung-Yil | - |
dc.contributor.author | Kil, Hong-Ryang | - |
dc.contributor.author | Kim, Gi Beom | - |
dc.contributor.author | Han, Myung-Ki | - |
dc.contributor.author | Song, Min Seob | - |
dc.contributor.author | Lee, Hyoung Doo | - |
dc.contributor.author | Ha, Kee Soo | - |
dc.contributor.author | Hong, Young Mi | - |
dc.contributor.author | Jang, Gi Young | - |
dc.contributor.author | Lee, Jong-Keuk | - |
dc.contributor.author | Yu, Jeong Jin | - |
dc.contributor.author | Yu, Jeong Jin | - |
dc.contributor.author | Park, In-Sook | - |
dc.contributor.author | Hong, Soo-Jong | - |
dc.contributor.author | Kim, Kwi-Joo | - |
dc.contributor.author | Lee, Jong-Keuk | - |
dc.contributor.author | Kim, Jae-Jung | - |
dc.contributor.author | Hong, Young Mi | - |
dc.contributor.author | Sohn, Sejung | - |
dc.contributor.author | Jang, Gi Young | - |
dc.contributor.author | Ha, Kee Soo | - |
dc.contributor.author | Nam, Hyo-Kyoung | - |
dc.contributor.author | Byeon, Jung-Hye | - |
dc.contributor.author | Yun, Sin Weon | - |
dc.contributor.author | Han, Myung-Ki | - |
dc.contributor.author | Jun, Hyun Ok | - |
dc.contributor.author | Lee, Kyung-Yil | - |
dc.contributor.author | Hwang, Ja-Young | - |
dc.contributor.author | Rhim, Jung-Woo | - |
dc.contributor.author | Song, Min Seob | - |
dc.contributor.author | Lee, Hyoung Doo | - |
dc.contributor.author | Kim, Dong Soo | - |
dc.contributor.author | Yoon, Kyung Lim | - |
dc.contributor.author | Kil, Hong-Ryang | - |
dc.contributor.author | Kim, Gi Beom | - |
dc.contributor.author | Lee, Jae-Moo | - |
dc.contributor.author | Kim, Jong-Duk | - |
dc.date.accessioned | 2022-03-15T15:42:51Z | - |
dc.date.available | 2022-03-15T15:42:51Z | - |
dc.date.created | 2021-12-24 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 1434-5161 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139084 | - |
dc.description.abstract | Kawasaki disease (KD) is an acute, self-limited vasculitis, mainly affecting children younger than 5 years old, with accompanying fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) is the standard treatment for KD; however, similar to 15% of patients are resistant to IVIG treatment. To identify protein coding genetic variants influencing IVIG resistance, we re-analyzed our previous genome-wide association study (GWAS) data from 296 patients with KD, including 101 IVIG non-responders and 195 IVIG responders. Five nonsynonymous SNPs (nsSNPs) in five immune-related genes, including a previously reported SAMD9L nsSNP (rs10488532; p.Val266Ile), were associated with IVIG non-response (odds ratio [OR] = 1.89-3.46, P = 0.0109-0.0035). In a replication study of the four newly-identified nsSNPs, only one in the interleukin 16 (IL16) gene (rs11556218, p.Asn1147Lys) showed a trend of association with IVIG non-response (OR = 1.54, P = 0.0078). The same IL16 nsSNP was more significantly associated with IVIG non-response in combined analysis of all data (OR = 1.64, P = 1.25 x 10(-4)). Furthermore, risk allele combination of the IL16 CT and SAMD9L TT nsSNP genotypes exhibited a very strong effect size (OR = 9.19, P = 3.63 x 10(-4)). These results implicate IL16 as involved in the mechanism of IVIG resistance in KD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | LONG-TERM MANAGEMENT | - |
dc.subject | HEALTH-PROFESSIONALS | - |
dc.subject | INTERLEUKIN 16 | - |
dc.subject | EXPRESSION | - |
dc.subject | PREDICTION | - |
dc.subject | STATEMENT | - |
dc.subject | DIAGNOSIS | - |
dc.subject | THERAPY | - |
dc.subject | FAILURE | - |
dc.subject | CELLS | - |
dc.title | Association of the IL16 Asn1147Lys polymorphism with intravenous immunoglobulin resistance in Kawasaki disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Gi Young | - |
dc.contributor.affiliatedAuthor | Ha, Kee Soo | - |
dc.identifier.doi | 10.1038/s10038-020-0721-2 | - |
dc.identifier.scopusid | 2-s2.0-85078108243 | - |
dc.identifier.wosid | 000508513800001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HUMAN GENETICS, v.65, no.4, pp.421 - 426 | - |
dc.relation.isPartOf | JOURNAL OF HUMAN GENETICS | - |
dc.citation.title | JOURNAL OF HUMAN GENETICS | - |
dc.citation.volume | 65 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 421 | - |
dc.citation.endPage | 426 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | HEALTH-PROFESSIONALS | - |
dc.subject.keywordPlus | INTERLEUKIN 16 | - |
dc.subject.keywordPlus | LONG-TERM MANAGEMENT | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | STATEMENT | - |
dc.subject.keywordPlus | THERAPY | - |
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