Rapid detection of FMO3 single nucleotide polymorphisms using a pyrosequencing method
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jin-Woo | - |
dc.contributor.author | Park, In-Hwan | - |
dc.contributor.author | Kim, Jong-Min | - |
dc.contributor.author | Noh, Ji Hyeon | - |
dc.contributor.author | Kim, Kyoung-Ah | - |
dc.contributor.author | Park, Ji-Young | - |
dc.date.accessioned | 2022-04-01T17:40:23Z | - |
dc.date.available | 2022-04-01T17:40:23Z | - |
dc.date.created | 2022-04-01 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139385 | - |
dc.description.abstract | The present study aimed to develop a reliable pyrosequencing method to detect four single nucleotide polymorphisms (SNPs) of the flavin-containing monooxygenase 3 (FMO3) gene and to compare the ethnic differences in their allelic frequencies. The pyrosequencing method was used to detect four FMO3 SNPs, namely, c.855C>T (N285N, rs909530), c.441C>T (S147S, rs1800822), c.923A>G (E308G, rs2266780) and c.472G>A (E158K, rs2266782). The allelic frequencies of these SNPs in 122 unrelated Korean subjects were as follows: i) 44.7% for c.855C>T; ii) 23.4% for c.441C>T; iii) 23.0% for c.923A>G; and iv) 27.1% for c.472G>A. Linkage disequilibrium (LD) analysis revealed that the SNPs c.923A>G and c.472G>A exhibited a strong LD (D '=0.8289, r(2)=0.5332). In conclusion, the pyrosequencing method developed in this study was successfully applied to detect the c.855C>T, c.441C>T, c.923A>G and c.472G>A SNPs of FMO3. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | CONTAINING-MONOOXYGENASE 3 | - |
dc.subject | DRUG-METABOLISM | - |
dc.subject | TRIMETHYLAMINURIA | - |
dc.subject | VARIANTS | - |
dc.title | Rapid detection of FMO3 single nucleotide polymorphisms using a pyrosequencing method | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Ji-Young | - |
dc.identifier.doi | 10.3892/mmr.2021.12564 | - |
dc.identifier.scopusid | 2-s2.0-85121207867 | - |
dc.identifier.wosid | 000731681700001 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.25, no.2 | - |
dc.relation.isPartOf | MOLECULAR MEDICINE REPORTS | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | CONTAINING-MONOOXYGENASE 3 | - |
dc.subject.keywordPlus | DRUG-METABOLISM | - |
dc.subject.keywordPlus | TRIMETHYLAMINURIA | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordAuthor | pyrosequencing | - |
dc.subject.keywordAuthor | c | - |
dc.subject.keywordAuthor | 855C> | - |
dc.subject.keywordAuthor | T | - |
dc.subject.keywordAuthor | c | - |
dc.subject.keywordAuthor | 441C> | - |
dc.subject.keywordAuthor | T | - |
dc.subject.keywordAuthor | c | - |
dc.subject.keywordAuthor | 923A> | - |
dc.subject.keywordAuthor | G | - |
dc.subject.keywordAuthor | c | - |
dc.subject.keywordAuthor | 472G> | - |
dc.subject.keywordAuthor | A | - |
dc.subject.keywordAuthor | flavin-containing monooxygenase 3 | - |
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