Epidemiology and Long-Term Adverse Outcomes in Korean Patients with Congenital Adrenal Hyperplasia: A Nationwide Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Hee | - |
dc.contributor.author | Choi, Sunkyu | - |
dc.contributor.author | Lee, Young Ah | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.date.accessioned | 2022-04-01T18:41:11Z | - |
dc.date.available | 2022-04-01T18:41:11Z | - |
dc.date.created | 2022-04-01 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139393 | - |
dc.description.abstract | Background: Previous studies on the epidemiology and complications of congenital adrenal hyperplasia (CAH) were conducted in Western countries and in children/adolescents. We aimed to explore the epidemiology of CAH, as well as the risk of comorbidities and mortality, in a Korean nationwide case-control study. Methods: CAH patients (n=2,840) were included between 2002 and 2017 from the National Health Insurance Service database and the Rare Intractable Disease program. CAH patients were compared, at a 1:10 ratio, with age-, sex-, and index year-matched controls (n = 28,400). Results: The point prevalence of CAH patients in Korea was 1 in 18,745 persons in 2017. The annual incidence rate declined between 2003 and 2017 from 3.25 to 0.41 per 100,000 persons. CAH patients were at elevated risk for cardiovascular disease (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.4 to 1.9), stroke (OR, 1.7; 95% CI, 1.3 to 2.0), diabetes mellitus (OR, 2.8; 95% CI, 2.6 to 3.1). dyslipidemia (OR 2.4; 95% CI, 2.2 to 2.6), and psychiatric disorders (OR, 1.5; 95% CI, 1.3 to 1.6). Fracture risk increased in CAH patients aged over 40 years (OR, 1.4; 95% CI, 1.1 to 1.7). CAH patients were at higher risk of mortality than controls ratio, 1.6; 95% CI, 1.3 to 2.0). Conclusion: Our nationwide study showed a recent decline in the incidence of CAH and an elevated risk for cardiovascular, metabolic, skeletal, and psychiatric disorders in CAH patients. Lifelong management for comoibidity risk is a crucial component of treating CAH patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.subject | 21-HYDROXYLASE DEFICIENCY | - |
dc.subject | ADULT PATIENTS | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | HEALTH OUTCOMES | - |
dc.subject | COHORT | - |
dc.subject | UPDATE | - |
dc.subject | WOMEN | - |
dc.subject | BORN | - |
dc.title | Epidemiology and Long-Term Adverse Outcomes in Korean Patients with Congenital Adrenal Hyperplasia: A Nationwide Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.identifier.doi | 10.3803/EnM.2021.1328 | - |
dc.identifier.scopusid | 2-s2.0-85126717218 | - |
dc.identifier.wosid | 000764890400013 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.37, no.1, pp.138 - 147 | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 138 | - |
dc.citation.endPage | 147 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002814994 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | 21-HYDROXYLASE DEFICIENCY | - |
dc.subject.keywordPlus | ADULT PATIENTS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | HEALTH OUTCOMES | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | BORN | - |
dc.subject.keywordAuthor | Adrenal hyperplasia | - |
dc.subject.keywordAuthor | congenital | - |
dc.subject.keywordAuthor | Epidemiology | - |
dc.subject.keywordAuthor | Long term adverse effects | - |
dc.subject.keywordAuthor | Comorbidity | - |
dc.subject.keywordAuthor | Mortality | - |
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