Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Taehyeong | - |
dc.contributor.author | Ham, So-Young | - |
dc.contributor.author | Nam, SangJin | - |
dc.contributor.author | Kim, Myoungsun | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Park, Hee-Deung | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.date.accessioned | 2022-04-01T19:40:55Z | - |
dc.date.available | 2022-04-01T19:40:55Z | - |
dc.date.created | 2022-04-01 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139397 | - |
dc.description.abstract | Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. P. aeruginosa forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in P. aeruginosa, is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | QUORUM-SENSING INHIBITORS | - |
dc.subject | ACTIVE EFFLUX | - |
dc.subject | QUINOLONE SIGNAL | - |
dc.subject | LASR MUTANTS | - |
dc.subject | RESISTANCE | - |
dc.subject | VIRULENCE | - |
dc.subject | RECEPTOR | - |
dc.subject | POTENT | - |
dc.subject | EXPRESSION | - |
dc.subject | MODULATORS | - |
dc.title | Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.contributor.affiliatedAuthor | Park, Hee-Deung | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.3390/antibiotics11020274 | - |
dc.identifier.scopusid | 2-s2.0-85125045264 | - |
dc.identifier.wosid | 000767688000001 | - |
dc.identifier.bibliographicCitation | ANTIBIOTICS-BASEL, v.11, no.2 | - |
dc.relation.isPartOf | ANTIBIOTICS-BASEL | - |
dc.citation.title | ANTIBIOTICS-BASEL | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | QUORUM-SENSING INHIBITORS | - |
dc.subject.keywordPlus | ACTIVE EFFLUX | - |
dc.subject.keywordPlus | QUINOLONE SIGNAL | - |
dc.subject.keywordPlus | LASR MUTANTS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | VIRULENCE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MODULATORS | - |
dc.subject.keywordAuthor | Pseudomonas aeruginosa | - |
dc.subject.keywordAuthor | RhlR | - |
dc.subject.keywordAuthor | biofilm | - |
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