Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01)
DC Field | Value | Language |
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dc.contributor.author | Kang, Eun Joo | - |
dc.contributor.author | Lee, Yun-Gyoo | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Choi, Jin-Hyuk | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Park, Keon Uk | - |
dc.contributor.author | Lee, Kyoung Eun | - |
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Shin, Seong Hoon | - |
dc.contributor.author | Lee, Jii Bum | - |
dc.contributor.author | Kwon, Jung Hye | - |
dc.contributor.author | Kim, Hye Ryun | - |
dc.contributor.author | Kim, Sung-Bae | - |
dc.contributor.author | Yun, Hwan Jung | - |
dc.date.accessioned | 2022-04-01T23:40:33Z | - |
dc.date.available | 2022-04-01T23:40:33Z | - |
dc.date.created | 2022-04-01 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139421 | - |
dc.description.abstract | Background/Aims: Treatment decisions for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are complicated, and multi-modal treatments are usually indicated. However, it is challenging for older patients to complete treatments. Thus, we investigated disease characteristics, real-world treatment, and outcomes in older LA-HNSCC patients. Methods: Older patients (aged >= 70 years) were selected from a large nationwide cohort that included 445 patients with stage III-IVB LA-HNSCC from January 2005 to December 2015. Their data were retrospectively analyzed and compared with those of younger patients. Results: Older patients accounted for 18.7% (83/445) of all patients with median age was 73 years (range, 70 to 89). Proportions of primary tumors in the hypopharynx and larynx were higher in older patients and older patients had a more advanced T stage and worse performance status. Regarding treatment strategies of older patients, 44.5% of patients received concurrent chemoradiotherapy (CCRT), 41.0% underwent surgery, and 14.5% did not complete the planned treatment. Induction chemotherapy (IC) was administered to 27.7% (23/83) of older patients; the preferred regimen for IC was fluorouracil and cisplatin (47.9%). For CCRT, weekly cisplatin was prescribed 3.3 times more often than 3-weekly cisplatin (62.2% vs. 18.9%). Older patients had a 60% higher risk of death than younger patients (hazard ratio, 1.6; p = 0.035). Oral cavity cancer patients had the worst survival probability. Conclusions: Older LA-HNSCC patients had aggressive tumor characteristics and received less intensive treatment, resulting in poor survival. Further research focusing on the older population is necessary. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | SQUAMOUS-CELL CARCINOMA | - |
dc.subject | INDUCTION CHEMOTHERAPY | - |
dc.subject | ELDERLY-PATIENTS | - |
dc.subject | UNRESECTABLE HEAD | - |
dc.subject | CISPLATIN | - |
dc.subject | FLUOROURACIL | - |
dc.subject | CARE | - |
dc.subject | CHEMORADIOTHERAPY | - |
dc.subject | METAANALYSIS | - |
dc.subject | DOCETAXEL | - |
dc.title | Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Eun Joo | - |
dc.identifier.doi | 10.3904/kjim.2020.636 | - |
dc.identifier.scopusid | 2-s2.0-85123391279 | - |
dc.identifier.wosid | 000737495600001 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.37, no.1, pp.190 - + | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002787641 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | INDUCTION CHEMOTHERAPY | - |
dc.subject.keywordPlus | ELDERLY-PATIENTS | - |
dc.subject.keywordPlus | UNRESECTABLE HEAD | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | CARE | - |
dc.subject.keywordPlus | CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DOCETAXEL | - |
dc.subject.keywordAuthor | Aged | - |
dc.subject.keywordAuthor | Head and neck neoplasms | - |
dc.subject.keywordAuthor | Therapeutics | - |
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