Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Seyoung | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Li, Mingle | - |
dc.contributor.author | Zhang, Xingcai | - |
dc.contributor.author | Pu, Kanyi | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2022-04-02T09:40:23Z | - |
dc.date.available | 2022-04-02T09:40:23Z | - |
dc.date.created | 2022-04-01 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139495 | - |
dc.description.abstract | Despite extensive efforts to realize effective photodynamic therapy (PDT), there is still a lack of therapeutic approaches concisely structured to mitigate the major obstacles of PDT in clinical applications. Herein, we report a molecular strategy exploiting ascorbate chemistry to enhance the efficacy of PDT in cancer cells overexpressing glucose transporter 1 (GLUT1). AA-EtNBS, a 5-O-substituted ascorbate-photosensitizer (PS) conjugate, undergoes a reversible structural conversion of the ascorbate moiety in the presence of reactive oxygen species (ROS) and glutathione (GSH), thereby promoting its uptake in GLUT1-overexpressed KM12C colon cancer cells and perturbing tumor redox homeostasis, respectively. Due to the unique pro-oxidant role of ascorbate in tumor environments, AA-EtNBS effectively sensitized KM12C cancer cells prior to PS-mediated generation of superoxide radicals under near-infrared (NIR) illumination. AA-EtNBS successfully exhibited GLUT1-targeted synergistic therapeutic efficacy during PDT both in vitro and in vivo. Therefore, this study outlines a promising strategy employing ascorbate both as a targeting unit for GLUT1-overexpressed cancer cells and redox homeostasis destruction agent, thereby enhancing therapeutic responses towards anticancer treatment when used in conjunction with conventional PDT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | VITAMIN-C | - |
dc.subject | DEHYDROASCORBIC ACID | - |
dc.subject | CANCER-CELLS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | TRANSPORT | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | OXIDATION | - |
dc.subject | EMISSION | - |
dc.title | Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.identifier.doi | 10.1002/anie.202110832 | - |
dc.identifier.scopusid | 2-s2.0-85125542597 | - |
dc.identifier.wosid | 000763535100001 | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.61, no.17 | - |
dc.relation.isPartOf | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 61 | - |
dc.citation.number | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | VITAMIN-C | - |
dc.subject.keywordPlus | DEHYDROASCORBIC ACID | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | EMISSION | - |
dc.subject.keywordAuthor | Ascorbate | - |
dc.subject.keywordAuthor | GLUT1 | - |
dc.subject.keywordAuthor | Phototherapeutics | - |
dc.subject.keywordAuthor | Pro-Oxidant | - |
dc.subject.keywordAuthor | Targeted Therapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.