Bariatric surgery versus medical therapy in Korean obese patients: prospective multicenter nonrandomized controlled trial (KOBESS trial)
- Authors
- Park, Do Joong; An, Sena; Park, Young Suk; Lee, Joo-Ho; Lee, Hyuk-Joon; Ha, Tae Kyung; Kim, Yong-Jin; Ryu, Seung-Wan; Han, Sang-Moon; Yoo, Moon-Won; Park, Sungsoo; Han, Sang-Uk; Kang, Jae-Heon; Kwon, Jin-Won; Heo, Yoonseok
- Issue Date
- 10월-2021
- Publisher
- KOREAN SURGICAL SOCIETY
- Keywords
- Asia; Bariatric surgery; Metabolic diseases; Obesity
- Citation
- ANNALS OF SURGICAL TREATMENT AND RESEARCH, v.101, no.4, pp.197 - 205
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- Volume
- 101
- Number
- 4
- Start Page
- 197
- End Page
- 205
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/139548
- DOI
- 10.4174/astr.2021.101.4.197
- ISSN
- 2288-6575
- Abstract
- Purpose: The aim of this study was to show that bariatric surgery (BS) is more effective than medical therapy (MT) in Asian obese patients. Methods: In this prospective, multicenter, nonrandomized, controlled trial, obese patients with body mass index of >= 35 kg/m(2) or 30.0-34.9 kg/m(2) with obesity-related comorbidities were assigned to undergo BS, such as laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass, or MT. Patients who underwent BS were evaluated 4, 12, 24, and 48 weeks after surgery, whereas patients who received MT were monitored at a hospital every 6 weeks for 1 year. At each visit, weight, waist and hip circumference, and blood pressure were measured, and patients underwent physical examination and laboratory testing. Health-related quality of life (HQOL) was investigated using Euro QOL-5 Dimension, Impact of Weight on Quality of Life questionnaire-Lite and Obesity-related Problems scale. Results: The study included 264 patients from 13 institutions; of these, 64 underwent BS and 200 received MT. Of the patients who underwent BS, 6.3% experienced early complications. Relative weight changes from baseline to 48 weeks were significantly greater in the BS than in the MT group (26.9% vs. 2.1%, P < 0.001), as were the rates of remission of diabetes (47.8% vs. 16.7%, P = 0.014), hypertension (60.0% vs. 26.1%, P < 0.001), and dyslipidemia (63.2% vs. 22.0%, P < 0.001). HQOL was better in the BS than in the MT group at 48 weeks. Conclusion: BS was safe and effective in Korean obese patients, with greater weight reduction, remission of comorbidities, and quality of life improvement than MT.
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