Integrative functional genomic analysis of human brain development and neuropsychiatric risks
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안준용 | - |
dc.date.accessioned | 2022-04-09T02:40:45Z | - |
dc.date.available | 2022-04-09T02:40:45Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139707 | - |
dc.description.abstract | To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Analysis of gene coexpression modules revealed relationships with epigenomic regulation and neurodevelopmental processes. Genes with genetic associations to brain-based traits and neuropsychiatric disorders (including MEF2C, SATB2, SOX5, TCF4, and TSHZ3) converged in a small number of modules and distinct cell types, revealing insights into neurodevelopment and the genomic basis of neuropsychiatric risks. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Integrative functional genomic analysis of human brain development and neuropsychiatric risks | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 안준용 | - |
dc.identifier.bibliographicCitation | SCIENCE, v.362, no.6420, pp.1264 - 1264 | - |
dc.relation.isPartOf | SCIENCE | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 362 | - |
dc.citation.number | 6420 | - |
dc.citation.startPage | 1264 | - |
dc.citation.endPage | 1264 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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