Collective helicity switching of a DNA-coat assembly
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용주 | - |
dc.date.accessioned | 2022-04-09T23:40:42Z | - |
dc.date.available | 2022-04-09T23:40:42Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1748-3387 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139834 | - |
dc.description.abstract | Hierarchical assemblies of biomolecular subunits can carry out versatile tasks at the cellular level with remarkable spatial and temporal precision(1,2). As an example, the collective motion and mutual cooperation between complex protein machines mediate essential functions for life, such as replication(3), synthesis(4), degradation(5), repair(6) and transport(7). Nucleic acid molecules are far less dynamic than proteins and need to bind to specific proteins to form hierarchical structures. The simplest example of these nucleic acid-based structures is provided by a rod-shaped tobacco mosaic virus, which consists of genetic material surrounded by coat proteins(8). Inspired by the complexity and hierarchical assembly of viruses, a great deal of effort has been devoted to design similarly constructed artificial viruses(9,10). However, such a wrapping approach makes nucleic acid dynamics insensitive to environmental changes. This limitation generally restricts, for example, the amplification of the conformational dynamics between the right-handed B form to the left-handed Z form of double-stranded deoxyribonucleic acid (DNA)(11,12). Here we report a virus-like hierarchical assembly in which the native DNA and a synthetic coat undergo repeated collective helicity switching triggered | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Collective helicity switching of a DNA-coat assembly | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김용주 | - |
dc.identifier.doi | 10.1038/NNANO.2017.42 | - |
dc.identifier.bibliographicCitation | NATURE NANOTECHNOLOGY, v.12, no.6, pp.551 - 551 | - |
dc.relation.isPartOf | NATURE NANOTECHNOLOGY | - |
dc.citation.title | NATURE NANOTECHNOLOGY | - |
dc.citation.volume | 12 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 551 | - |
dc.citation.endPage | 551 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.