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The Highly Evolvable Antibody Fc Domain

Authors
정상택
Issue Date
11월-2016
Publisher
ELSEVIER SCIENCE LONDON
Citation
TRENDS IN BIOTECHNOLOGY, v.34, no.11, pp.895 - 908
Indexed
SCIE
SCOPUS
Journal Title
TRENDS IN BIOTECHNOLOGY
Volume
34
Number
11
Start Page
895
End Page
908
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/139864
DOI
10.1016/j.tibtech.2016.04.005
ISSN
0167-7799
Abstract
The Fc region of the IgG antibody recruits immune leukocytes or serum complement molecules, which in turn triggers the clearance of defective cells such as tumor cells or infected cells. In addition, the Fc region is crucial for the prolonged serum persistence of circulating IgG antibodies through an intracellular trafficking and recycling mechanism. Recently, the utility of antibody Fc has been further expanded to include a new class of antigen-binding scaffolds. This review presents the recent progress in the field of antibody Fc engineering and highlights new biomolecular, cellular, and evolutionary approaches to overcome the limitations of conventional monoclonal therapeutic antibodies by engineering the antibody Fc domain.
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