Genetic heterogeneity in autism: From single gene to a pathway perspective
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안준용 | - |
dc.date.accessioned | 2022-04-10T06:40:19Z | - |
dc.date.available | 2022-04-10T06:40:19Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0149-7634 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139867 | - |
dc.description.abstract | The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major challenge. Recent advances in genetic screening and systems biology approaches have extended our knowledge of the genetic etiology of ASD. In this review, we discuss the paradigm shift from a single gene causation model to pathway perturbation model as a guide to better understand the pathophysiology of ASD. We discuss recent genetic findings obtained through next-generation sequencing (NGS) and examine various integrative analyses using systems biology and complex networks approaches that identify convergent patterns of genetic elements associated with ASD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER LTD | - |
dc.title | Genetic heterogeneity in autism: From single gene to a pathway perspective | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 안준용 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v.68, pp.442 - 453 | - |
dc.relation.isPartOf | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | - |
dc.citation.title | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | - |
dc.citation.volume | 68 | - |
dc.citation.startPage | 442 | - |
dc.citation.endPage | 453 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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