Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희진 | - |
dc.date.accessioned | 2022-04-10T07:41:06Z | - |
dc.date.available | 2022-04-10T07:41:06Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/139876 | - |
dc.description.abstract | In chemical synthesis, rapid intramolecular rearrangements often foil attempts at site-selective bimolecular functionalization. We developed a microfluidic technique that outpaces the very rapid anionic Fries rearrangement to chemoselectively functionalize iodophenyl carbamates at the ortho position. Central to the technique is a chip microreactor of our design, which can deliver a reaction time in the submillisecond range even at cryogenic temperatures. The microreactor was applied to the synthesis of afesal, a bioactive molecule exhibiting anthelmintic activity, to demonstrate its potential for practical synthesis and production. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김희진 | - |
dc.identifier.doi | 10.1126/science.aaf1389 | - |
dc.identifier.bibliographicCitation | SCIENCE, v.352, no.6286, pp.691 - 694 | - |
dc.relation.isPartOf | SCIENCE | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 352 | - |
dc.citation.number | 6286 | - |
dc.citation.startPage | 691 | - |
dc.citation.endPage | 694 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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