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Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system

Authors
안준용
Issue Date
3월-2014
Publisher
NATURE PUBLICATION GROUP
Citation
MOLECULAR PSYCHIATRY, v.19, no.3, pp.294 - 301
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR PSYCHIATRY
Volume
19
Number
3
Start Page
294
End Page
301
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/139965
ISSN
1359-4184
Abstract
Many putative genetic factors that confer risk to neurodevelopmental disorders such as autism spectrum disorders (ASDs) and X-linked intellectual disability (XLID), and to neuropsychiatric disorders including attention deficit hyperactivity disorder (ADHD) and schizophrenia (SZ) have been identified in individuals from diverse human populations. Although there is significant aetiological heterogeneity within and between these conditions, recent data show that genetic factors contribute to their comorbidity. Many studies have identified candidate gene associations for these mental health disorders, albeit this is often done in a piecemeal fashion with little regard to the inherent molecular complexity. Here, we sought to abstract relationships from our knowledge of systems level biology to help understand the unique and common genetic drivers of these conditions. We undertook a global and systematic approach to build and integrate available data in gene networks associated with ASDs, XLID, ADHD and SZ. Complex network concepts and computational methods were used to investigate whether candidate genes associated with these conditions were related through mechanisms of gene regulation, functional protein-protein interactions, transcription factor (TF) and microRNA (miRNA) binding si
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