Directional Assembly of alpha-Helical Peptides Induced by Cyclization
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용주 | - |
dc.date.accessioned | 2022-04-11T12:45:03Z | - |
dc.date.available | 2022-04-11T12:45:03Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140020 | - |
dc.description.abstract | Effective stabilization of short peptide chains into a helical structure has been a challenge in the fields of chemistry and biology. Here we report a novel method for alpha-helix stabilization of short peptides through their confinement in a cyclic architecture. We synthesized block peptides based on a short peptide and a flexible linker as linear precursors. Subsequent cyclization of the peptide precursors resulted in a conformational change of the peptide unit from a random coil to an alpha-helix. The incorporation of hydrophobic residues into the peptide unit led to a facially amphiphilic conformation of the molecular cycle. The resulting amphiphilic peptide self-assembled into undulated nanofibers through the directional assembly of small oblate micelles. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Directional Assembly of alpha-Helical Peptides Induced by Cyclization | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김용주 | - |
dc.identifier.doi | 10.1021/ja3098756 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, no.50, pp.20270 - 20272 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 134 | - |
dc.citation.number | 50 | - |
dc.citation.startPage | 20270 | - |
dc.citation.endPage | 20272 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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