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Heteroaromatic Moieties in the Sphingosine Backbone of alpha-Galactosylceramides for Noncovalent Interactions with CD1d
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 김용주 | - |
| dc.date.accessioned | 2022-04-11T14:44:38Z | - |
| dc.date.available | 2022-04-11T14:44:38Z | - |
| dc.date.created | 2022-04-08 | - |
| dc.date.issued | 2012-02 | - |
| dc.identifier.issn | 19485875 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140030 | - |
| dc.description.abstract | A series of alpha-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of alpha-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | AMER CHEMICAL SOC | - |
| dc.title | Heteroaromatic Moieties in the Sphingosine Backbone of alpha-Galactosylceramides for Noncovalent Interactions with CD1d | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | 김용주 | - |
| dc.identifier.doi | 10.1021/ml200278u | - |
| dc.identifier.bibliographicCitation | ACS MEDICINAL CHEMISTRY LETTERS, v.3, no.2, pp.151 - 154 | - |
| dc.relation.isPartOf | ACS MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.title | ACS MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 3 | - |
| dc.citation.number | 2 | - |
| dc.citation.startPage | 151 | - |
| dc.citation.endPage | 154 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordAuthor | CD1d | - |
| dc.subject.keywordAuthor | alpha-Galactosylceramide | - |
| dc.subject.keywordAuthor | cytokine secretion | - |
| dc.subject.keywordAuthor | noncovalent interaction | - |
| dc.subject.keywordAuthor | selectivity | - |
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