Integrated micro flow synthesis based on sequential Br-Li exchange reactions of p-, m-, and o-dibromobenzenes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희진 | - |
dc.date.accessioned | 2022-04-11T20:42:17Z | - |
dc.date.available | 2022-04-11T20:42:17Z | - |
dc.date.created | 2022-04-08 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140060 | - |
dc.description.abstract | A micro flow system consisting of micromixers and microtube reactors provides an effective method for the introduction of two electrophiles onto p-, m-, and o-dibromobenzenes. The Br-Li exchange reaction of p-dibromobenzene with nBuLi can be conducted by using the micro flow system at 20 degrees C, although much lower temperatures (< -48 degrees C) are needed for a batch reaction. The resulting p-bromophenyllithium was allowed to react with an electrophile in the micro flow system at 20 degrees C. The p-substituted bromobenzene thus obtained was subjected to a second Br-Li exchange reaction followed by reaction with a second electrophile at 20 degrees C in one flow. A similar transformation can be carried out with m-dibromobenzene by using the micro flow system. However, the Br-Li exchange reaction of o-dibromobenzene followed by reaction with an electrophile should be conducted at -78 degrees C to avoid benzyne formation. The second Br-Li exchange reaction followed by reaction with an electrophile can be carried out at 0 degrees C. By using the present method, a variety of p-, m-, and o-disubstituted benzenes were synthesized in one flow at much higher temperatures than are required for conventional batch reactions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Integrated micro flow synthesis based on sequential Br-Li exchange reactions of p-, m-, and o-dibromobenzenes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김희진 | - |
dc.identifier.doi | 10.1002/asia.200700231 | - |
dc.identifier.bibliographicCitation | CHEMISTRY-AN ASIAN JOURNAL, v.2, no.12, pp.1513 - 1523 | - |
dc.relation.isPartOf | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.title | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.volume | 2 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1513 | - |
dc.citation.endPage | 1523 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | arenes | - |
dc.subject.keywordAuthor | flow reactions | - |
dc.subject.keywordAuthor | integrated micro flow synthesis | - |
dc.subject.keywordAuthor | lithiation | - |
dc.subject.keywordAuthor | microreactors | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.