Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Young | - |
dc.contributor.author | Eom, Youngsub | - |
dc.contributor.author | Yoon, Eun Gyu | - |
dc.contributor.author | Song, Jong Suk | - |
dc.contributor.author | Kim, Il-Hwan | - |
dc.contributor.author | Kim, Hyo Myung | - |
dc.date.accessioned | 2022-04-12T02:42:25Z | - |
dc.date.available | 2022-04-12T02:42:25Z | - |
dc.date.created | 2022-04-12 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0277-3740 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140075 | - |
dc.description.abstract | Purpose: The purpose of this study was to evaluate the efficacy of topical ivermectin 1% cream application on the eyelashes in combination with eyelid hygiene in the treatment of Demodex blepharitis. Methods: One hundred two eyes of 102 patients with symptomatic Demodex blepharitis were divided into 2 groups according to the use of topical ivermectin in this retrospective case-control study. The ivermectin group (n = 51) applied topical ivermectin 1% cream on the eyelashes for 15 minutes once weekly, but the control group (n = 51) did not. In both groups, eyelid hygiene was performed once daily. The Standard Patient Evaluation of Eye Dryness (SPEED) symptom questionnaire score, Oxford staining score, eyelid debris, eyelid redness/swelling, and telangiectasia were assessed during the follow-up visits. Results: The mean follow-up periods of the ivermectin and control groups were 15.1 +/- 9.7 weeks and 14.8 +/- 8.6 weeks, respectively. The SPEED score and eyelid debris grade were significantly improved in both groups during the follow-up, although the SPEED score and eyelid debris grade showed greater changes in the ivermectin group than in the control group. The Oxford staining score, eyelid redness/swelling grade, and telangiectasia grade were significantly improved only in the ivermectin group but not in the control group. Conclusions: In patients with Demodex blepharitis, the use of topical ivermectin 1% cream for 15 minutes once weekly in addition to eyelid hygiene had more significantly improved symptoms, ocular surface staining, eyelid debris, redness/swelling, and telangiectasia as compared with eyelid hygiene alone. These findings support the efficacy of topical ivermectin 1% cream application in the treatment of Demodex blepharitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | TEA TREE OIL | - |
dc.subject | ORAL IVERMECTIN | - |
dc.subject | METRONIDAZOLE | - |
dc.subject | THERAPY | - |
dc.subject | FOLLICULORUM | - |
dc.subject | DEMODICOSIS | - |
dc.subject | ROSACEA | - |
dc.subject | LESIONS | - |
dc.subject | SCRUB | - |
dc.title | Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eom, Youngsub | - |
dc.identifier.doi | 10.1097/ICO.0000000000002802 | - |
dc.identifier.scopusid | 2-s2.0-85125883881 | - |
dc.identifier.wosid | 000764244300011 | - |
dc.identifier.bibliographicCitation | CORNEA, v.41, no.4, pp.427 - 434 | - |
dc.relation.isPartOf | CORNEA | - |
dc.citation.title | CORNEA | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 427 | - |
dc.citation.endPage | 434 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | TEA TREE OIL | - |
dc.subject.keywordPlus | ORAL IVERMECTIN | - |
dc.subject.keywordPlus | METRONIDAZOLE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | FOLLICULORUM | - |
dc.subject.keywordPlus | DEMODICOSIS | - |
dc.subject.keywordPlus | ROSACEA | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | SCRUB | - |
dc.subject.keywordAuthor | Demodex | - |
dc.subject.keywordAuthor | demodicosis | - |
dc.subject.keywordAuthor | ivermectin | - |
dc.subject.keywordAuthor | blepharitis | - |
dc.subject.keywordAuthor | eyelid hygiene | - |
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