Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, C. | - |
dc.contributor.author | Kim, J.-Y. | - |
dc.contributor.author | Lee, E.J. | - |
dc.contributor.author | Kang, Y.M. | - |
dc.contributor.author | Song, K.-H. | - |
dc.contributor.author | Kim, E.S. | - |
dc.contributor.author | Kim, E.J. | - |
dc.contributor.author | Sheen, S. | - |
dc.contributor.author | Lee, Y.R. | - |
dc.contributor.author | Kang, B. | - |
dc.contributor.author | Kim, J.H. | - |
dc.contributor.author | Woo, M.L. | - |
dc.contributor.author | Park, C.H. | - |
dc.contributor.author | Kwon, S. | - |
dc.contributor.author | Choo, E.J. | - |
dc.contributor.author | Kim, T. | - |
dc.contributor.author | Kim, D. | - |
dc.contributor.author | Oh, H.S. | - |
dc.contributor.author | Choi, W.S. | - |
dc.date.accessioned | 2022-04-12T19:41:57Z | - |
dc.date.available | 2022-04-12T19:41:57Z | - |
dc.date.created | 2022-04-12 | - |
dc.date.issued | 2022-03-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140158 | - |
dc.description.abstract | Reports detailing the clinical characteristics, viral load, and outcomes of patients with normal initial chest CT findings are lacking. We sought to compare the differences in clinical findings, viral loads, and outcomes between patients with confirmed COVID-19 who initially tested negative on chest CT (CT negative) with patients who tested initially positive on chest CT (CT positive). The clinical data, viral loads, and outcomes of initial CT-positive and CTnegative patients examined between January 2020 and April 2020 were retrospectively compared. The efficacy of viral load (cyclic threshold value [Ct value]) in predicting pneumonia was evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC). In total, 128 patients underwent initial chest CT (mean age, 54.3 ± 19.0 years, 50% male). Of those, 36 were initially CT negative, and 92 were CT positive. The CT-positive patients were significantly older (P < .001) than the CT-negative patients. Only age was significantly associated with the initial presence of pneumonia (odds ratio, 1.060; confidence interval (CI), 1.020-1-102; P = .003). In addition, age (OR, 1.062; CI, 1.014-1.112; P = .011), fever at diagnosis (OR, 6.689; CI, 1.715-26.096; P = .006), and CRP level (OR, 1.393; CI, 1.150-1.687; P = .001) were significantly associated with the need for O2 therapy. Viral load was significantly higher in the CT-positive group than in the CT-negative group (P = .017). The cutoff Ct value for predicting the presence of pneumonia was 27.71. Outcomes including the mean hospital stay, intensive care unit admission, and O2 therapy were significantly worse in the CT-positive group than in the CT-negative group (all P < .05). In conclusion, initially CT-negative patients showed better outcomes than initially CT-positive patients. Age was significantly associated with the initial presence of pneumonia, and viral load may help in predicting the initial presence of pneumonia. © 2022 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.title | Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, C. | - |
dc.identifier.doi | 10.1371/journal.pone.0264711 | - |
dc.identifier.scopusid | 2-s2.0-85125692134 | - |
dc.identifier.wosid | 000776002200066 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.17, no.3 March | - |
dc.relation.isPartOf | PLoS ONE | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 March | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.