(TfNNN)-N-15: A gamma-N-15-Labeled Diazo-Transfer Reagent for the Synthesis of beta-N-15-Labeled Azides
DC Field | Value | Language |
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dc.contributor.author | Kwon, Hyeok-Jun | - |
dc.contributor.author | Gwak, Sungduk | - |
dc.contributor.author | Park, Jun Young | - |
dc.contributor.author | Cho, Minhaeng | - |
dc.contributor.author | Han, Hogyu | - |
dc.date.accessioned | 2022-04-13T02:42:17Z | - |
dc.date.available | 2022-04-13T02:42:17Z | - |
dc.date.created | 2022-04-12 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140194 | - |
dc.description.abstract | Azides are infrared (IR) probes that are important for structure and dynamics studies of proteins. However, they often display complex IR spectra owing to Fermi resonances and multiple conformers. Isotopic substitution of azides weakens the Fermi resonance, allowing more accurate IR spectral analysis. Site-specifically N-15-labeled aromatic azides, but not aliphatic azides, are synthesized through nitrosation. Both N-15-labeled aromatic and aliphatic azides are synthesized through nucleophilic substitution or diazo-transfer reaction but as an isotopomeric mixture. We present the synthesis of (TfNNN)-N-15, a gamma-N-15-labeled diazo-transfer reagent, and its use to prepare beta-N-15-labeled aliphatic as well as aromatic azides. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | FERMI RESONANCE | - |
dc.subject | BETA-AZIDOALANINE | - |
dc.subject | CLICK CHEMISTRY | - |
dc.subject | ELECTRIC-FIELDS | - |
dc.subject | IR PROBE | - |
dc.subject | DIAZOTRANSFER | - |
dc.subject | CONVERSION | - |
dc.subject | EFFICIENT | - |
dc.subject | DERIVATIVES | - |
dc.subject | VIBRATIONS | - |
dc.title | (TfNNN)-N-15: A gamma-N-15-Labeled Diazo-Transfer Reagent for the Synthesis of beta-N-15-Labeled Azides | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Hogyu | - |
dc.identifier.doi | 10.1021/acsomega.1c04679 | - |
dc.identifier.scopusid | 2-s2.0-85122745284 | - |
dc.identifier.wosid | 000739887600001 | - |
dc.identifier.bibliographicCitation | ACS OMEGA, v.7, no.1, pp.293 - 298 | - |
dc.relation.isPartOf | ACS OMEGA | - |
dc.citation.title | ACS OMEGA | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 293 | - |
dc.citation.endPage | 298 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | FERMI RESONANCE | - |
dc.subject.keywordPlus | BETA-AZIDOALANINE | - |
dc.subject.keywordPlus | CLICK CHEMISTRY | - |
dc.subject.keywordPlus | ELECTRIC-FIELDS | - |
dc.subject.keywordPlus | IR PROBE | - |
dc.subject.keywordPlus | DIAZOTRANSFER | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | VIBRATIONS | - |
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