Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model
DC Field | Value | Language |
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dc.contributor.author | Choi, Jung-Woo | - |
dc.contributor.author | Lee, Joonbum | - |
dc.contributor.author | Lee, Yuseon | - |
dc.contributor.author | Seo, Ji-Hun | - |
dc.contributor.author | Hong, Kwang Dae | - |
dc.date.accessioned | 2022-04-18T04:42:20Z | - |
dc.date.available | 2022-04-18T04:42:20Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2050-7518 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140257 | - |
dc.description.abstract | Fecal incontinence is a disabling condition in which the passage of fecal material cannot be controlled. Although the condition is not life-threatening, it can seriously reduce the quality of life of a patient by isolating them from others. Though various surgical treatments are available for moderate to severe symptoms, a bulking agent is a minimally invasive technique that has attracted attention because of its safety and simple treatment process. However, the biocompatibility of bulking agent materials remains a central issue, with their durability questioned because immune responses and/or the circulatory system may remove the bulking agent in vivo. This study investigated a bulking agent composed of polydimethylsiloxane and hyaluronic acid as a microfiller and carrier gel, respectively. To improve the injectability of the bulking agent, the filler size was tuned using a suspension-based fabrication technique. To evade immune responses, the filler surface was treated with a zwitterionic polymer that simultaneously functionalized and stabilized the material interfaces. The resulting bulking agent exhibited good injectability and biocompatibility in vitro, with 58% lower protein adsorption and no cytotoxicity, leading to an improved bulking effect in a preclinical rat model compared with a bulking agent without surface treatment. These results illustrate the promising potential of bulking agents as a therapy for fecal incontinence with reduced foreign body reactions and long-lasting efficacy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jung-Woo | - |
dc.contributor.affiliatedAuthor | Seo, Ji-Hun | - |
dc.contributor.affiliatedAuthor | Hong, Kwang Dae | - |
dc.identifier.doi | 10.1039/d1tb02341a | - |
dc.identifier.scopusid | 2-s2.0-85128245390 | - |
dc.identifier.wosid | 000754042100001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.10, no.14, pp.2708 - 2718 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 10 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 2708 | - |
dc.citation.endPage | 2718 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | PARTICLE-SIZE DISTRIBUTION | - |
dc.subject.keywordPlus | SUSPENSION | - |
dc.subject.keywordPlus | SPHINCTER | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | IMPLANTS | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | GEL | - |
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