Association between interleukin-10 polymorphisms and juvenile idiopathic arthritis: a meta-analysis
- Authors
- Jung, Jae Hyun; Kim, Jae-Hoon; Song, Gwan Gyu; Choi, Sung Jae
- Issue Date
- 2월-2022
- Publisher
- EDIZIONI MINERVA MEDICA
- Keywords
- Interleukin-10; Genetic polymorphism; Juvenile arthritis; Meta-analysis
- Citation
- MINERVA PEDIATRICS, v.74, no.1, pp.81 - 89
- Indexed
- SCIE
SCOPUS
- Journal Title
- MINERVA PEDIATRICS
- Volume
- 74
- Number
- 1
- Start Page
- 81
- End Page
- 89
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/140293
- DOI
- 10.23736/S2724-5276.18.05369-0
- ISSN
- 2724-5276
- Abstract
- INTRODUCTION: The aim of this review is to investigate IL-10 polymorphisms (-1082 G/A, -819 C/T, and -592 C/A) and their association with susceptibility to JIA. EVIDENCE ACQUISITION: A meta-analysis was conducted after database search for relevant articles (MEDLINE and EMBASE). EVIDENCE SYNTHESIS: A total of seven studies involving 1495 patients and 1670 controls were considered in the meta-analysis. There was no association between the IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and JIA in allele contrast and any of the genetic models (allele contrast: odds ratio [OR] 0.90, 95% confidence interval [CI] 0.791.02, P=0.09; OR=0.97, 95% CI 0.83-1.13, P=0.68; OR=0.92, 95% CI 0.81-1.06, P=0.24, respectively). In subgroup analysis, none of the subtypes of JIA including systemic, rheumatoid factor (RF)-positive polyarticular, RF-negative polyarticular, and oligoarticular was not significantly associated with IL-10 polymorphism. Meta-analysis of the IL-10 haplotype revealed no association between GCC, ACC, and ATA haplotypes and JIA. CONCLUSIONS: This meta-analysis showed that IL-10 polymorphisms were not associated with risk of JIA.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.