Deficiency in RCAT-1 Function Causes Dopamine Metabolism Related Behavioral Disorders in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Jeong, H. | - |
dc.contributor.author | Park, J.Y. | - |
dc.contributor.author | Lee, J.-H. | - |
dc.contributor.author | Baik, J.-H. | - |
dc.contributor.author | Kim, C.-Y. | - |
dc.contributor.author | Cho, J.-Y. | - |
dc.contributor.author | Driscoll, M. | - |
dc.contributor.author | Paik, Y.-K. | - |
dc.date.accessioned | 2022-04-18T17:42:20Z | - |
dc.date.available | 2022-04-18T17:42:20Z | - |
dc.date.created | 2022-04-18 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140322 | - |
dc.description.abstract | When animals are faced with food depletion, food search-associated locomotion is crucial for their survival. Although food search-associated locomotion is known to be regulated by dopamine, it has yet to investigate the potential molecular mechanisms governing the regulation of genes involved in dopamine metabolism (e.g., cat-1, cat-2) and related behavioral disorders. During the studies of the pheromone ascaroside, a signal of starvation stress in C. elegans, we identified R02D3.7, renamed rcat-1 (regulator of cat genes-1), which had previously been shown to bind to regulatory sequences of both cat-1 and cat-2 genes. It was found that RCAT-1 (R02D3.7) is expressed in dopaminergic neurons and functions as a novel negative transcriptional regulator for cat-1 and cat-2 genes. When a food source becomes depleted, the null mutant, rcat-1(ok1745), exhibited an increased frequency of high-angled turns and intensified area restricted search behavior compared to the wild-type animals. Moreover, rcat-1(ok1745) also showed defects in state-dependent olfactory adaptation and basal slowing response, suggesting that the mutants are deficient in either sensing food or locomotion toward food. However, rcat-1(ok1745) has normal cuticular structures and locomotion genes. The discovery of rcat-1 not only identifies a new subtype of dopamine-related behaviors but also provides a potential therapeutic target in Parkinson’s disease. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Deficiency in RCAT-1 Function Causes Dopamine Metabolism Related Behavioral Disorders in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, J.-H. | - |
dc.identifier.doi | 10.3390/ijms23042393 | - |
dc.identifier.scopusid | 2-s2.0-85124903801 | - |
dc.identifier.wosid | 000778586600001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.23, no.4 | - |
dc.relation.isPartOf | International Journal of Molecular Sciences | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | LIFE-SPAN EXTENSION | - |
dc.subject.keywordPlus | DYSREGULATION SYNDROME | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | INTEGRATIVE ANALYSIS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | FOOD | - |
dc.subject.keywordPlus | LEVODOPA | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.subject.keywordAuthor | Dopamine | - |
dc.subject.keywordAuthor | Dopamine dysregulation syndrome | - |
dc.subject.keywordAuthor | Parkinson’s disease | - |
dc.subject.keywordAuthor | Tyrosine hydroxylase | - |
dc.subject.keywordAuthor | Vesicular monoamine transporter | - |
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