Liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosisLiver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis
- Other Titles
- Liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis
- Authors
- 김상진; 김종만
- Issue Date
- 2021
- Publisher
- 대한간암학회
- Keywords
- Hepatocellular carcinoma; Portal vein; Thrombosis; Liver transplantation
- Citation
- Journal of Liver Cancer, v.21, no.2, pp.105 - 112
- Indexed
- KCI
- Journal Title
- Journal of Liver Cancer
- Volume
- 21
- Number
- 2
- Start Page
- 105
- End Page
- 112
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/140340
- ISSN
- 2288-8128
- Abstract
- Traditionally, liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis is not recommended. However, with recent developments in locoregional therapies for hepatocellular carcinoma, more aggressive treatments have been attempted for advanced hepatocellular carcinoma. Recently, various studies on locoregional therapies fordownstaging followed by living donor liver transplantation reported inspiring overall survival and recurrence-free survival of patients. These downstaging procedures included threedimensional conformal radiation therapy, trans-arterial chemoembolization, stereotactic body radiation therapy, trans-arterial radioembolization, hepatic arterial infusion chemotherapy and combinations of these therapies. Selection of the optimal downstaging protocol should depend on tumor location, biology and background liver status. The risk factors affecting outcome include pre-downstaging alpha-fetoprotein values, delta alpha-fetoprotein values, disappearance of portal vein tumor thrombosis on imaging and meeting the Milan criteria or not after downstaging. For hepatocellular carcinoma with portal vein tumor thrombosis, downstaging procedure with liver transplantation in mind would be helpful. If the reaction of the downstaged tumor is good, liver transplantation may be performed.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.