2-Methoxyestradiol Inhibits Radiation-Induced Skin Injuries
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji-Hee | - |
dc.contributor.author | Nam, Jae-Kyung | - |
dc.contributor.author | Kim, A-Ram | - |
dc.contributor.author | Park, Min-Sik | - |
dc.contributor.author | Lee, Hae-June | - |
dc.contributor.author | Park, Joonho | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Lee, Yoon-Jin | - |
dc.date.accessioned | 2022-05-09T11:41:51Z | - |
dc.date.available | 2022-05-09T11:41:51Z | - |
dc.date.created | 2022-05-09 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140826 | - |
dc.description.abstract | Radiation-induced skin injury (RISI) is a main side effect of radiotherapy for cancer patients, with vascular damage being a common pathogenesis of acute and chronic RISI. Despite the severity of RISI, there are few treatments for it that are in clinical use. 2-Methoxyestradiol (2-ME) has been reported to regulate the radiation-induced vascular endothelial-to-mesenchymal transition. Thus, we investigated 2-ME as a potent anti-cancer and hypoxia-inducible factor 1 alpha (HIF-1 alpha) inhibitor drug that prevents RISI by targeting HIF-1 alpha. 2-ME treatment prior to and post irradiation inhibited RISI on the skin of C57/BL6 mice. 2-ME also reduced radiation-induced inflammation, skin thickness, and vascular fibrosis. In particular, post-treatment with 2-ME after irradiation repaired the damaged vessels on the irradiated dermal skin, inhibiting endothelial HIF-1 alpha expression. In addition to the increase in vascular density, post-treatment with 2-ME showed fibrotic changes in residual vessels with SMA(+)CD31(+) on the irradiated skin. Furthermore, 2-ME significantly inhibited fibrotic changes and accumulated DNA damage in irradiated human dermal microvascular endothelial cells. Therefore, we suggest that 2-ME may be a potent therapeutic agent for RISI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | FIBROSIS | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | CELLS | - |
dc.title | 2-Methoxyestradiol Inhibits Radiation-Induced Skin Injuries | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.3390/ijms23084171 | - |
dc.identifier.scopusid | 2-s2.0-85127891180 | - |
dc.identifier.wosid | 000785366600001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.8 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | 2-Methoxyestradiol | - |
dc.subject.keywordAuthor | radiation-induced skin injury | - |
dc.subject.keywordAuthor | HIF 1-alpha | - |
dc.subject.keywordAuthor | vascular fibrosis | - |
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