Effects of Sphingomyelin-Containing Milk Phospholipids on Skin Hydration in UVB-Exposed Hairless Mice
DC Field | Value | Language |
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dc.contributor.author | Ahn, Yejin | - |
dc.contributor.author | Kim, Min Guk | - |
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2022-05-09T12:42:12Z | - |
dc.date.available | 2022-05-09T12:42:12Z | - |
dc.date.created | 2022-05-09 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/140832 | - |
dc.description.abstract | Reactive oxygen species (ROS) generated by ultraviolet (UV) exposure cause skin barrier dysfunction, which leads to dry skin. In this study, the skin moisturizing effect of sphingomyelin-containing milk phospholipids in UV-induced hairless mice was evaluated. Hairless mice were irradiated with UVB for eight weeks, and milk phospholipids (50, 100, and 150 mg/kg) were administered daily. Milk phospholipids suppressed UV-induced increase in erythema and skin thickness, decreased transepidermal water loss, and increased skin moisture. Milk phospholipids increased the expression of filaggrin, involucrin, and aquaporin3 (AQP3), which are skin moisture-related factors. Additionally, hyaluronic acid (HA) content in the skin tissue was maintained by regulating the expression of HA synthesis- and degradation-related enzymes. Milk phospholipids alleviated UV-induced decrease in the expression of the antioxidant enzymes superoxidase dismutase1 and 2, catalase, and glutathione peroxidase1. Moreover, ROS levels were reduced by regulating heme oxygenase-1 (HO-1), an ROS regulator, through milk phospholipid-mediated activation of nuclear factor erythroid-2-related factor 2 (Nrf2). Collectively, sphingomyelin-containing milk phospholipids contributed to moisturizing the skin by maintaining HA content and reducing ROS levels in UVB-irradiated hairless mice, thereby, minimizing damage to the skin barrier caused by photoaging. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | HYALURONIC-ACID | - |
dc.subject | DEGRADATION | - |
dc.subject | MODEL | - |
dc.subject | EXPRESSION | - |
dc.subject | EXTRACT | - |
dc.subject | PATHWAY | - |
dc.subject | DAMAGE | - |
dc.title | Effects of Sphingomyelin-Containing Milk Phospholipids on Skin Hydration in UVB-Exposed Hairless Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.3390/molecules27082545 | - |
dc.identifier.scopusid | 2-s2.0-85128800786 | - |
dc.identifier.wosid | 000785037200001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.27, no.8 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordAuthor | milk phospholipids | - |
dc.subject.keywordAuthor | sphingomyelin | - |
dc.subject.keywordAuthor | skin hydration | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
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