2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy
DC Field | Value | Language |
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dc.contributor.author | Xu, Yunjie | - |
dc.contributor.author | Wang, Yingwei | - |
dc.contributor.author | An, Jusung | - |
dc.contributor.author | Sedgwick, Adam C. | - |
dc.contributor.author | Li, Mingle | - |
dc.contributor.author | Xie, Jianlei | - |
dc.contributor.author | Hu, Weibin | - |
dc.contributor.author | Kang, Jianlong | - |
dc.contributor.author | Sen, Sajal | - |
dc.contributor.author | Steinbrueck, Axel | - |
dc.contributor.author | Zhang, Bin | - |
dc.contributor.author | Qiao, Lijun | - |
dc.contributor.author | Wageh, Swelm | - |
dc.contributor.author | Arambula, Jonathan F. | - |
dc.contributor.author | Liu, Liping | - |
dc.contributor.author | Zhang, Han | - |
dc.contributor.author | Sessler, Jonathan L. | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2022-05-17T02:41:43Z | - |
dc.date.available | 2022-05-17T02:41:43Z | - |
dc.date.created | 2022-05-17 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 2452-199X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141075 | - |
dc.description.abstract | An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target. Unfortunately, current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities. We report here a dual-therapeutic prodrug, DOXjade, that allows for iron chelation chemo-photothermal cancer therapy. This prodrug takes advantage of the clinically approved iron chelator deferasirox (ExJade (R)) and the topoisomerase 2 inhibitor, doxorubicin (DOX). Loading DOXjade onto ultrathin 2D Ti3C2 MXene nanosheets produces a construct, Ti3C2-PVP@DOXjade, that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites, while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%. Antitumor mechanistic investigations reveal that upon activation, Ti3C2-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor (TfR). A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo. The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KEAI PUBLISHING LTD | - |
dc.subject | CANCER | - |
dc.subject | DEFERASIROX | - |
dc.title | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.bioactmat.2021.12.011 | - |
dc.identifier.scopusid | 2-s2.0-85121468126 | - |
dc.identifier.wosid | 000788639700004 | - |
dc.identifier.bibliographicCitation | BIOACTIVE MATERIALS, v.14, pp.76 - 85 | - |
dc.relation.isPartOf | BIOACTIVE MATERIALS | - |
dc.citation.title | BIOACTIVE MATERIALS | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 76 | - |
dc.citation.endPage | 85 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DEFERASIROX | - |
dc.subject.keywordAuthor | 2D MXene | - |
dc.subject.keywordAuthor | Nanomedi cine | - |
dc.subject.keywordAuthor | Prodrug | - |
dc.subject.keywordAuthor | Iron chelation | - |
dc.subject.keywordAuthor | Photothermal therapy | - |
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