Association of delayed initiation of non-invasive respiratory support with pulmonary air leakage in outborn late-preterm and term neonates
DC Field | Value | Language |
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dc.contributor.author | Choi, Eui Kyung | - |
dc.contributor.author | Park, Kyu Hee | - |
dc.contributor.author | Choi, Byung Min | - |
dc.date.accessioned | 2022-05-17T08:42:04Z | - |
dc.date.available | 2022-05-17T08:42:04Z | - |
dc.date.created | 2022-05-17 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0340-6199 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141106 | - |
dc.description.abstract | The frequency of non-invasive respiratory support use has increased in neonates of all gestational ages with respiratory distress (RD). However, the impact of delayed initiation of non-invasive respiratory support in outborn neonates remains poorly understood. This study aimed to identify the impact of the delayed initiation of non-invasive respiratory support in outborn, late-preterm, and term neonates. Medical records of 277 infants (gestational age of >= 35 weeks) who received non-invasive respiratory support as primary respiratory therapy < 24 h of age between 2016 and 2020 were retrospectively reviewed. Factors associated with respiratory adverse outcomes were investigated in 190 outborn neonates. Infants with RD were divided into two groups: mild (fraction of inspired oxygen [FiO(2)] <= 0.3) and moderate-to-severe RD (FiO(2) > 0.3), depending on their initial oxygen requirements from non-invasive respiratory support. The median time for the initiation of non-invasive respiratory support at a tertiary center was 3.5 (2.2-5.0) h. Male sex, a high oxygen requirement (FiO(2) > 0.3), high CO2 level, and respiratory distress syndrome were significant factors associated with adverse outcomes. Subgroup analysis revealed that in the moderate-to-severe RD group, delayed commencement of non-invasive respiratory support (>= 3 h) was significantly associated with pulmonary air leakage (p = 0.033). Conclusion: Our study shows that outborn neonates with moderate-to-severe RD, who were treated with delayed non-invasive respiratory support, were associated with an increased likelihood of pulmonary air leakage. Additional prospective studies are required to establish the optimal timing and methods of non-invasive respiratory support for outborn, late-preterm, and term infants. What is Known: center dot Non-invasive respiratory support is widely used in neonates of all gestational ages. center dot Little is known on the impact of delayed initiation of non-invasive respiratory support in outborn, late preterm, and term neonates. What is New: center dot Male sex, high oxygen requirement (FiO2 >0.3), high initial CO2 level, and respiratory distress syndrome significantly correlated with adverse outcomes. center dot Outborn late-preterm and term neonates with high oxygen requirement who were treated with delayed non-invasive respiratory support indicated an increased likelihood of pulmonary air leakage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | DISTRESS-SYNDROME | - |
dc.subject | PRESSURE | - |
dc.subject | INFANTS | - |
dc.subject | PNEUMOTHORAX | - |
dc.subject | FAILURE | - |
dc.subject | OXYGEN | - |
dc.subject | CPAP | - |
dc.title | Association of delayed initiation of non-invasive respiratory support with pulmonary air leakage in outborn late-preterm and term neonates | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Byung Min | - |
dc.identifier.doi | 10.1007/s00431-021-04317-3 | - |
dc.identifier.scopusid | 2-s2.0-85122869001 | - |
dc.identifier.wosid | 000741627600004 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PEDIATRICS, v.181, no.4, pp.1651 - 1660 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PEDIATRICS | - |
dc.citation.title | EUROPEAN JOURNAL OF PEDIATRICS | - |
dc.citation.volume | 181 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1651 | - |
dc.citation.endPage | 1660 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | DISTRESS-SYNDROME | - |
dc.subject.keywordPlus | PRESSURE | - |
dc.subject.keywordPlus | INFANTS | - |
dc.subject.keywordPlus | PNEUMOTHORAX | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | CPAP | - |
dc.subject.keywordAuthor | Respiratory distress syndrome | - |
dc.subject.keywordAuthor | Outborn | - |
dc.subject.keywordAuthor | Newborn | - |
dc.subject.keywordAuthor | Continuous positive airway pressure | - |
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