Integration of Genomic Profiling and Organoid Development in Precision Oncologyopen access
- Authors
- Yoon, Hyunho; Lee, Sanghoon
- Issue Date
- 1월-2022
- Publisher
- MDPI
- Keywords
- precision oncology; next-generation sequencing; organoids; genome profiling; breast cancer; ovarian cancer
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 23
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/141125
- DOI
- 10.3390/ijms23010216
- ISSN
- 1661-6596
- Abstract
- Precision oncology involves an innovative personalized treatment strategy for each cancer patient that provides strategies and options for cancer treatment. Currently, personalized cancer medicine is primarily based on molecular matching. Next-generation sequencing and related technologies, such as single-cell whole-transcriptome sequencing, enable the accurate elucidation of the genetic landscape in individual cancer patients and consequently provide clinical benefits. Furthermore, advances in cancer organoid models that represent genetic variations and mutations in individual cancer patients have direct and important clinical implications in precision oncology. This review aimed to discuss recent advances, clinical potential, and limitations of genomic profiling and the use of organoids in breast and ovarian cancer. We also discuss the integration of genomic profiling and organoid models for applications in cancer precision medicine.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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