Conditional deletion of TMEM16A in cholinergic neurons of the medial habenula induces anhedonic-like behavior in mice
DC Field | Value | Language |
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dc.contributor.author | Song, Jae Gwang | - |
dc.contributor.author | Kwon, Osung | - |
dc.contributor.author | Hwang, Eun Mi | - |
dc.contributor.author | Kim, Hyung Wook | - |
dc.contributor.author | Park, Jae-Yong | - |
dc.date.accessioned | 2022-06-09T10:40:59Z | - |
dc.date.available | 2022-06-09T10:40:59Z | - |
dc.date.created | 2022-06-09 | - |
dc.date.issued | 2022-05-24 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141724 | - |
dc.description.abstract | The medial habenula (mHb), a subregion of the habenula, is involved in diverse brain functions, such as nicotine addiction, anxiety, and anhedonia. We recently reported that TMEM16A deficiency, a calcium-activated chloride channel, decreased the activity of mHb cholinergic neurons. Since downregulated activity in cholinergic neurons of the mHb is involved in anhedonia-like behavior, we here investigated whether conditional deletion of TMEM16A in mHb cholinergic neurons also displays anhedonia-like behavior. The conditional deletion of TMEM16A in the mHb cholinergic neurons of mice (TMEM16A cKO mice) was generated by crossing ChaT-Cre (+) with floxed TMEM16A f/f mice. TMEM16A cKO mice displayed significantly reduced social interaction, sucrose preference, female urine sniffing, and increased marble burying. These behavioral data suggest the potential role of TMEM16A in anhedonic-like behavior in mice. Taken together, the presented data suggest that TMEM16A-mediated mHb activity might be a therapeutic target for anhedonia-related symptoms. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | OBSESSIVE-COMPULSIVE DISORDER | - |
dc.subject | ANXIETY | - |
dc.subject | DEPRESSION | - |
dc.subject | ADDICTION | - |
dc.subject | SYMPTOMS | - |
dc.subject | STRESS | - |
dc.title | Conditional deletion of TMEM16A in cholinergic neurons of the medial habenula induces anhedonic-like behavior in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jae-Yong | - |
dc.identifier.doi | 10.1016/j.bbr.2022.113841 | - |
dc.identifier.scopusid | 2-s2.0-85126724506 | - |
dc.identifier.wosid | 000790347500002 | - |
dc.identifier.bibliographicCitation | BEHAVIOURAL BRAIN RESEARCH, v.426 | - |
dc.relation.isPartOf | BEHAVIOURAL BRAIN RESEARCH | - |
dc.citation.title | BEHAVIOURAL BRAIN RESEARCH | - |
dc.citation.volume | 426 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | OBSESSIVE-COMPULSIVE DISORDER | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | ADDICTION | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordAuthor | TMEM16A | - |
dc.subject.keywordAuthor | Anhedonia | - |
dc.subject.keywordAuthor | Medial habenula | - |
dc.subject.keywordAuthor | Cholinergic neuron | - |
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