Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells
DC Field | Value | Language |
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dc.contributor.author | Min, Seongchun | - |
dc.contributor.author | Kim, Ji Yeon | - |
dc.contributor.author | Cho, Hyo Min | - |
dc.contributor.author | Park, Sujin | - |
dc.contributor.author | Hwang, Ji Min | - |
dc.contributor.author | You, Hyejin | - |
dc.contributor.author | Chae, Young Chan | - |
dc.contributor.author | Lee, Won-Jae | - |
dc.contributor.author | Sun, Woong | - |
dc.contributor.author | Kang, Dongmin | - |
dc.contributor.author | Lee, Sanghyuk | - |
dc.contributor.author | Kang, Sang Won | - |
dc.date.accessioned | 2022-06-09T16:40:54Z | - |
dc.date.available | 2022-06-09T16:40:54Z | - |
dc.date.created | 2022-06-09 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141753 | - |
dc.description.abstract | Mitochondria communicate with other cellular compartments via the secretion of protein factors. Here, we report an unexpected messenger role for heat shock protein 60 (HSP60) as a mitochondrial-releasing protein factor that couples stress-sensing signaling and cell survival machineries. We show that mild oxidative stress predominantly activates the p38/MK2 complex, which phosphorylates mitochondrial fission factor 1 (MFF1) at the S155 site. Such phosphorylated MFF1 leads to the oligomerization of voltage anion-selective channel 1, thereby triggering the formation of a mitochondrial membrane pore through which the matrix protein HSP60 passes. The liberated HSP60 associates with and activates the I kappa B kinase (IKK) complex in the cytosol, which consequently induces the NF-kappa B-dependent expression of survival genes in nucleus. Indeed, inhibition of the HSP60 release or HSP60-IKK interaction sensitizes the cancer cells to mild oxidative stress and regresses the tumorigenic growth of cancer cells in the mouse xenograft model. Thus, this study reveals a novel mitonuclear survival axis responding to oxidative stress. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | MITOCHONDRIAL FISSION | - |
dc.subject | PROTEINS | - |
dc.subject | RELEASE | - |
dc.subject | LIFE | - |
dc.subject | APOPTOSIS | - |
dc.subject | PATHWAYS | - |
dc.subject | ISCHEMIA | - |
dc.subject | INJURY | - |
dc.subject | DEATH | - |
dc.subject | HSP60 | - |
dc.title | Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-Kappa B survival machinery in cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sun, Woong | - |
dc.identifier.doi | 10.1016/j.redox.2022.102293 | - |
dc.identifier.scopusid | 2-s2.0-85126542460 | - |
dc.identifier.wosid | 000792002200005 | - |
dc.identifier.bibliographicCitation | REDOX BIOLOGY, v.51 | - |
dc.relation.isPartOf | REDOX BIOLOGY | - |
dc.citation.title | REDOX BIOLOGY | - |
dc.citation.volume | 51 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | MITOCHONDRIAL FISSION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | HSP60 | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Mitochondria | - |
dc.subject.keywordAuthor | p38 MAPK | - |
dc.subject.keywordAuthor | HSP60 | - |
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