Oncologic outcomes according to the level of disease burden in patients with metachronous distant metastases from uterine cervical cancer: a Korean Radiation Oncology Group study (KROG 18-10)
DC Field | Value | Language |
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dc.contributor.author | Park, Sunmin | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Park, Shin Hyung | - |
dc.contributor.author | Kim, Joo-Young | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Kim, Haeyoung | - |
dc.contributor.author | Kim, Yeon-Sil | - |
dc.contributor.author | Cho, Won Kyung | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Yang, Dae Sik | - |
dc.date.accessioned | 2022-06-09T18:41:07Z | - |
dc.date.available | 2022-06-09T18:41:07Z | - |
dc.date.created | 2022-06-09 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2005-0380 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141764 | - |
dc.description.abstract | Objective: This study aimed to evaluate the oncologic outcomes according to disease burden in uterine cervical cancer patients with metachronous distant metastases. Methods: Between 2005 and 2015, 163 patients with metachronous distant metastases from uterine cervical cancer after receiving a definitive therapy were evaluated at seven institutions in Korea. Low metastatic burden was defined as less than 5 metastatic sites, whereas high metastatic burden was others. Each metastasis site was divided based on the lymph node (LN) and organs affected. The overall survival (OS) and progression-free survival (PFS) were assessed. Cox proportional hazards models, including other clinical variables, were used to evaluate the survival outcomes. Results: The median follow-up duration was 22.2 months (range: 0.3-174.8 months). Para aortic LNs (56.4%), lungs (26.4%), supraclavicular LNs (18.4%), and peritoneum (13.5%) were found to be the common metastasis sites. Among 37 patients with a single metastasis, 17 (45.9%) had LN metastases and 20 (54.1%) had organ metastases. The 1-and 2-year OS rates were 73.9% and 55.0%, respectively, whereas the PFS rates were 67.2% and 42.9%, respectively. SCC Ag after recurrence and high metastatic burden were significant factors affecting the OS (p=0.004 and p<0.001, respectively). Distant organ recurrence, short disease-free interval (<= 2 years), and high metastatic burden were unfavorable factors for PFS (p=0.003, p=0.011, and p=0.002, respectively). Conclusion: A favorable oncologic outcome can be expected by performing salvage treatments in selected patients with a long disease-free interval, low metastatic burden, and/ or lymphatic-only metastasis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY | - |
dc.subject | COLORECTAL-CARCINOMA METASTASES | - |
dc.subject | HEPATIC RESECTION | - |
dc.subject | RECURRENT | - |
dc.subject | SURVIVAL | - |
dc.subject | LIVER | - |
dc.subject | SITE | - |
dc.title | Oncologic outcomes according to the level of disease burden in patients with metachronous distant metastases from uterine cervical cancer: a Korean Radiation Oncology Group study (KROG 18-10) | - |
dc.title.alternative | Oncologic outcomes according to the level of disease burden in patients with metachronous distant metastases from uterine cervical cancer: a Korean Radiation Oncology Group study (KROG 18-10) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Won Sup | - |
dc.identifier.doi | 10.3802/jgo.2022.33.e32 | - |
dc.identifier.scopusid | 2-s2.0-85128802624 | - |
dc.identifier.wosid | 000790361300008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GYNECOLOGIC ONCOLOGY, v.33, no.3, pp.1 - 12 | - |
dc.relation.isPartOf | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.title | JOURNAL OF GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002857999 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | RECURRENT | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordPlus | COLORECTAL-CARCINOMA METASTASES | - |
dc.subject.keywordPlus | HEPATIC RESECTION | - |
dc.subject.keywordAuthor | Uterine Cervical Neoplasm | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordAuthor | Metachronous Neoplasm | - |
dc.subject.keywordAuthor | Neoplasm Metastasis | - |
dc.subject.keywordAuthor | Lymphatic Metastasis | - |
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