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Cell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer's disease patient-derived induced pluripotent stem cellsopen access

Authors
Lee, Ju-HyunYoo, GeonChoi, JuhyunPark, Si-HyungShin, HyogeunPrasad, RenukaLee, YeuneheeAhn, Mee RyungCho, Il-JooSun, Woong
Issue Date
16-5월-2022
Publisher
BMC
Keywords
Cerebral organoid; Disease modeling; Alzheimer' s diseases; Cell-to-cell variation
Citation
MOLECULAR BRAIN, v.15, no.1
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR BRAIN
Volume
15
Number
1
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/141821
DOI
10.1186/s13041-022-00928-5
ISSN
1756-6606
Abstract
The cerebral organoid (CO) model has been used in the study of various neurodegenerative diseases owing to its physiological implications. However, the CO model may only be representative of certain clinical findings in affected patients, while some features are not recapitulated. In this study, we found that neurons in the CO model from patients with Alzheimer's disease were less responsive to depolarization, in contrast to previous reports. This difference may be partly attributed to the variations in brain spatial identity depending on the genetic background of the induced pluripotent stem cells. Our current observation raises concerns that the phenotypes observed in the CO model need to be carefully evaluated for their clinical implications.
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