Association of DNA Methylation of the NLRP3 Gene with Changes in Cortical Thickness in Major Depressive Disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Kyu-Man | - |
dc.contributor.author | Choi, Kwan Woo | - |
dc.contributor.author | Kim, Aram | - |
dc.contributor.author | Kang, Wooyoung | - |
dc.contributor.author | Kang, Youbin | - |
dc.contributor.author | Tae, Woo-Suk | - |
dc.contributor.author | Han, Mi-Ryung | - |
dc.contributor.author | Ham, Byung-Joo | - |
dc.date.accessioned | 2022-06-10T10:40:18Z | - |
dc.date.available | 2022-06-10T10:40:18Z | - |
dc.date.created | 2022-06-10 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141840 | - |
dc.description.abstract | The Nod-like receptor pyrin containing 3 (NLRP3) inflammasome has been reported to be a convergent point linking the peripheral immune response induced by psychological stress and neuroinflammatory processes in the brain. We aimed to identify differences in the methylation profiles of the NLRP3 gene between major depressive disorder (MDD) patients and healthy controls (HCs). We also investigated the correlation of the methylation score of loci in NLRP3 with cortical thickness in the MDD group using magnetic resonance imaging (MRI) data. A total of 220 patients with MDD and 82 HCs were included in the study, and genome-wide DNA methylation profiling of the NLRP3 gene was performed. Among the total sample, 88 patients with MDD and 74 HCs underwent T1-weighted structural MRI and were included in the neuroimaging-methylation analysis. We identified five significant differentially methylated positions (DMPs) in NLRP3. In the MDD group, the methylation scores of cg18793688 and cg09418290 showed significant positive or negative correlations with cortical thickness in the occipital, parietal, temporal, and frontal regions, which showed significant differences in cortical thickness between the MDD and HC groups. Our findings suggest that NLRP3 DNA methylation may predispose to depression-related brain structural changes by increasing NLRP3 inflammasome-related neuroinflammatory processes in MDD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | SURFACE-BASED ANALYSIS | - |
dc.subject | INFLAMMASOME ACTIVATION | - |
dc.subject | GEOMETRICALLY ACCURATE | - |
dc.subject | PREFRONTAL CORTEX | - |
dc.subject | BRAIN STRUCTURE | - |
dc.subject | METAANALYSIS | - |
dc.subject | CYTOKINE | - |
dc.subject | STRESS | - |
dc.subject | NEUROINFLAMMATION | - |
dc.subject | SEGMENTATION | - |
dc.title | Association of DNA Methylation of the NLRP3 Gene with Changes in Cortical Thickness in Major Depressive Disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ham, Byung-Joo | - |
dc.identifier.doi | 10.3390/ijms23105768 | - |
dc.identifier.scopusid | 2-s2.0-85130327453 | - |
dc.identifier.wosid | 000801960900001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.10 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | SURFACE-BASED ANALYSIS | - |
dc.subject.keywordPlus | INFLAMMASOME ACTIVATION | - |
dc.subject.keywordPlus | GEOMETRICALLY ACCURATE | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | BRAIN STRUCTURE | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | SEGMENTATION | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.subject.keywordAuthor | DNA methylation | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | NLRP3 | - |
dc.subject.keywordAuthor | major depressive disorder | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | magnetic resonance image | - |
dc.subject.keywordAuthor | neuroimaging | - |
dc.subject.keywordAuthor | cortical thickness | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.