Total Synthesis of Rucaparib br
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jinjae | - |
dc.contributor.author | Cheon, Cheol-Hong | - |
dc.date.accessioned | 2022-06-10T11:59:22Z | - |
dc.date.available | 2022-06-10T11:59:22Z | - |
dc.date.created | 2022-06-09 | - |
dc.date.issued | 2022-04-01 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141848 | - |
dc.description.abstract | A concise total synthesis of rucaparib, an FDA-approved drug for ovarian and prostate cancers, is reported. TheHeck reaction of the commercially available aryl iodide withacrylonitrile provided the desired (E)-2-aminocinnamonitrile deriva-tive. A subsequent imino-Stetter reaction of the aldimine derived from2-aminocinnamonitrile and aldehyde furnished indole-3-acetonitrilebearing the desired substituents at appropriate positions. Theconstruction of thefinal azepinone scaffold via reduction of thenitrile group followed by seven-membered lactamization affordedrucaparib. Notably, the synthesis of rucaparib is achieved usingcommercially available starting materials in only three separationoperations with 54% overall yield. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | NITRILES | - |
dc.subject | HYDROGENATION | - |
dc.subject | DERIVATIVES | - |
dc.subject | REDUCTION | - |
dc.title | Total Synthesis of Rucaparib br | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cheon, Cheol-Hong | - |
dc.identifier.doi | 10.1021/acs.joc.2c00083 | - |
dc.identifier.scopusid | 2-s2.0-85127699792 | - |
dc.identifier.wosid | 000784116400030 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORGANIC CHEMISTRY, v.87, no.7, pp.4813 - 4817 | - |
dc.relation.isPartOf | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.title | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.volume | 87 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 4813 | - |
dc.citation.endPage | 4817 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | NITRILES | - |
dc.subject.keywordPlus | HYDROGENATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | REDUCTION | - |
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