Association of High-Density Lipoprotein Cholesterol Phenotypes with the Risk of Cardiovascular Diseases and Mortality: A Cohort Study in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Ga Eun | - |
dc.contributor.author | Huh, Youn | - |
dc.contributor.author | Jung, Jin-Hyung | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Kim, Seon Mee | - |
dc.date.accessioned | 2022-06-10T16:40:22Z | - |
dc.date.available | 2022-06-10T16:40:22Z | - |
dc.date.created | 2022-06-09 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/141870 | - |
dc.description.abstract | Background: We investigated whether low high-density lipoprotein cholesterol (HDL-C) and isolated and non-isolated low HDL-C levels are associated with the risk of cardiovascular diseases and all-cause mortality among Korean adults. Methods: We included 8,665,841 individuals aged >= 20 years who had undergone a health examination provided by the Korean National Health Insurance Service (NHIS) in 2009 and were followed up until the end of 2018. The hazard ratios (HRs) and 95% confidence intervals (CIs) for study outcomes were calculated using multivariable Cox proportional hazard regression analysis. Results: During the 8.2 years of mean follow-up, myocardial infarction (MI), stroke, and all-cause mortality occurred in 81,431, 110,996, and 244,309 individuals, respectively. After adjusting for confounding variables (model 3), individuals with low HDL-C and lower HDL quartiles were associated with significantly increased risks of all three outcomes, compared to those with normal HDL-C and highest HDL-C quartile (all P<0.001), respectively. HRs for incident MI (1.28; 95% CI, 1.26 to 1.30), stroke (1.13; 95% CI, 1.11 to 1.15), and all-cause mortality (1.07; 95% CI, 1.05 to 1.08) increased in the non-isolated low HDL-C group compared to the normal HDL-C group. Isolated low HDL-C also showed an increase in the HRs of incident stroke (1.06; 95% CI, 1.04 to 1.08) and all-cause mortality (1.30; 95% CI, 1.28 to 1.32). Conclusion: Low HDL-C and non-isolated low HDL-C were associated with increased risk of MI, stroke, and all-cause mortality, and isolated low HDL-C was associated with incident stroke and all-cause mortality risk. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | LOW HDL CHOLESTEROL | - |
dc.subject | ARTERY-DISEASE | - |
dc.subject | DYSLIPIDEMIA | - |
dc.subject | NIACIN | - |
dc.subject | SERUM | - |
dc.title | Association of High-Density Lipoprotein Cholesterol Phenotypes with the Risk of Cardiovascular Diseases and Mortality: A Cohort Study in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seon Mee | - |
dc.identifier.doi | 10.3803/EnM.2021.1259 | - |
dc.identifier.wosid | 000792399100009 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.37, no.2, pp.261 - 271 | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 37 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 261 | - |
dc.citation.endPage | 271 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002834858 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | LOW HDL CHOLESTEROL | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | DYSLIPIDEMIA | - |
dc.subject.keywordPlus | NIACIN | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordAuthor | Low high-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | Non-isolated low high-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | Isolated low high-density lipoprotein cholesterol | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Mortality | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.