Efficacy and Safety of TJP-008 Compared to 2 L PEG with Ascorbate in Colon Cleansing: A Randomized Phase 3 Trialopen accessEfficacy and Safety of TJP-008 Compared to 2 L PEG with Ascorbate in Colon Cleansing: A Randomized Phase 3 Trial
- Other Titles
- Efficacy and Safety of TJP-008 Compared to 2 L PEG with Ascorbate in Colon Cleansing: A Randomized Phase 3 Trial
- Authors
- Koo, Ja Seol; Byeon, Jeong-Sik; Lee, Bo-In; Jung, Sung-Ae; Kim, Tae Il; Jeen, Yoon Tae
- Issue Date
- 2022
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Colonoscopy; Cathartics; Polyethylene glycols; Ascorbic acid; Safety
- Citation
- GUT AND LIVER, v.16, no.2, pp.259 - 268
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- GUT AND LIVER
- Volume
- 16
- Number
- 2
- Start Page
- 259
- End Page
- 268
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/142129
- DOI
- 10.5009/gnl210092
- ISSN
- 1976-2283
- Abstract
- Background/Aims: Polyethylene glycol (PEG)-based bowel preparations are effective cleans-ing agents for colonoscopy. However, they require relatively large volumes to be used even with agents such as 2 L PEG with ascorbate (2LPEG). This phase 3, randomized, single-blinded, multicenter, parallel-group study compared the efficacy of 1 L PEG with high-dose ascorbate, TJP-008, to 2LPEG. Methods: Patients undergoing colonoscopy were randomized (1:1:1) to receive TJP-008 as 1-day split dose (TJP-008-1) or 2-day split dose (TJP-008-2) regimen or to receive 2LPEG as a 2-day split dose regimen. Cleansing efficacy was evaluated using the Harefield Cleansing Scale. The primary endpoint was overall bowel cleansing success. Full analysis set (FAS) and per pro-tocol set (PPS) analyses were performed. Results: Of the 314 screened patients, efficacy was assessed in the following patient numbers (FAS/PPS): total (293/285), TJP-008-1 (98/94), TJP-008-2 (97/95), and 2LPEG (98/96). FAS revealed noninferiority between TJP-008 and 2LPEG with regard to overall success (TJP-008-2, 99.0%; TJP-008-1, 95.9%; 2LPEG, 94.9%; p=0.100 and p=0.733, respectively). PPS also showed noninferiority (p=0.721 and p=0.211, respectively). However, the PPS analyses showed a higher bowel cleansing score for TJP-008-2 for high-quality cleansing in the right colon (TJP-008-2 83.2% vs 2LPEG 62.5%; p=0.005). Conclusions: TJP-008 is a new low-volume cleansing agent with a colon cleansing efficacy comparable to that of standard 2LPEG that exhibits significant safety and tolerability. (Gut Liver, Published online November 23, 2021)
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