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Microfluidic electrode array chip for electrical stimulation-mediated axonal regeneration

Authors
Kim, Ji WoonChoi, Yoon YoungPark, Si-HyungHa, Jang HoLee, Hee UkKang, TaewookSun, WoongChung, Bong Geun
Issue Date
31-5월-2022
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.22, no.11, pp.2122 - 2130
Indexed
SCIE
SCOPUS
Journal Title
LAB ON A CHIP
Volume
22
Number
11
Start Page
2122
End Page
2130
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/142245
DOI
10.1039/d1lc01158h
ISSN
1473-0197
Abstract
The precise manipulation of the neural stem cell (NSC)-derived neural differentiation is still challenging, and there is a technological barrier to regulate the axonal regeneration in a controlled manner. Here, we developed a microfluidic chip integrated with a microelectrode array as an axonal guidance platform. The microfluidic electrode array chip consisted of two compartments and a bridge microchannel that could isolate and guide the axons. We demonstrated that the NSCs were largely differentiated into neural cells as the electric field was applied to the microfluidic electrode array chip. We also confirmed the synergistic effects of the electrical stimulation (ES) and neurotrophic factor (NF) on axonal outgrowth. This microfluidic electrode array chip can serve as a central nervous system (CNS) model for axonal injury and regeneration. Therefore, it could be a potentially powerful tool for an in vitro model of the axonal regeneration.
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