Altered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Park, Jung Hyun | - |
dc.contributor.author | Cho, Sun-Jung | - |
dc.contributor.author | Jo, Chulman | - |
dc.contributor.author | Park, Moon Ho | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Kim, Eun-Joo | - |
dc.contributor.author | Huh, Gi Yeong | - |
dc.contributor.author | Koh, Young Ho | - |
dc.date.accessioned | 2022-06-22T13:41:42Z | - |
dc.date.available | 2022-06-22T13:41:42Z | - |
dc.date.created | 2022-06-22 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2075-4426 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142269 | - |
dc.description.abstract | Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment and is suggested to play an indirect role in regulating A beta production and the pathophysiology of A beta deposition in brains. However, studies on the amount of TIMP-3 in bodily fluids of Alzheimer's disease (AD) patients have not been conducted. Here, we investigated the relationship between fluid TIMP-3 levels and AD pathology. We first showed that the fluid levels of TIMP-3 were lower in AD dementia patients compared with in non-AD patients. ELISA results revealed that plasma levels of TIMP-3 in 65 patients with AD were significantly lower than those in 115 healthy control subjects and 71 mild cognitive impairment (MCI) subjects. Furthermore, we found that cerebrospinal fluid (CSF) level of TIMP-3 was decreased in AD compared with that in healthy control. These data suggest that fluid TIMP-3 levels negatively correlated with progress of cognitive decline. Collectively, our study suggests that alterations of fluid TIMP-3 levels might be associated with AD pathology. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | MILD COGNITIVE IMPAIRMENT | - |
dc.subject | CEREBRAL AMYLOID ANGIOPATHY | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | TISSUE INHIBITOR | - |
dc.subject | ASSOCIATION WORKGROUPS | - |
dc.subject | DIAGNOSTIC GUIDELINES | - |
dc.subject | NATIONAL INSTITUTE | - |
dc.subject | CONVERTING-ENZYME | - |
dc.subject | MATRIX-METALLOPROTEINASE-9 | - |
dc.subject | BIOMARKER | - |
dc.title | Altered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Changsu | - |
dc.identifier.doi | 10.3390/jpm12050827 | - |
dc.identifier.scopusid | 2-s2.0-85130865100 | - |
dc.identifier.wosid | 000804350600001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERSONALIZED MEDICINE, v.12, no.5 | - |
dc.relation.isPartOf | JOURNAL OF PERSONALIZED MEDICINE | - |
dc.citation.title | JOURNAL OF PERSONALIZED MEDICINE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MILD COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | CEREBRAL AMYLOID ANGIOPATHY | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | TISSUE INHIBITOR | - |
dc.subject.keywordPlus | ASSOCIATION WORKGROUPS | - |
dc.subject.keywordPlus | DIAGNOSTIC GUIDELINES | - |
dc.subject.keywordPlus | NATIONAL INSTITUTE | - |
dc.subject.keywordPlus | CONVERTING-ENZYME | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE-9 | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordAuthor | TIMP-3 | - |
dc.subject.keywordAuthor | CSF | - |
dc.subject.keywordAuthor | Plasma | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
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